Core A: Administrative

项目摘要--核心A PPG的总体目标是确定导致肝细胞癌发病率增加的机制 癌症(HCC)与年龄的关系，并利用这一理解来开发和验证候选方法 加强早期发现和预防。要实现这些目标，需要一个跨学科的专家团队， 专门研究癌症和衰老生物学的不同分子和细胞方面的创新小鼠 模型和实验工具，以及核心设施，以最大限度地提高效率和促进协同作用。反过来，这又会导致 多管齐下的团队需要一个管理核心来支持和协调其活动。 教授们。彼得·D·亚当斯(桑福德·伯纳姆·普雷比医学发现研究所，拉霍亚)和杰拉尔德·S·亚当斯 沙德尔(Salk Institute，La Jolla)将担任多名PD/PI，亚当斯担任联系人PI。Shadel将会 领导项目1和亚当斯项目2。其他项目负责人是Susan Kaech教授(Salk Institute，La Jolla；Project 3)和冯根生教授(加州大学圣地亚哥分校；项目4)。P01还集成了 三个核心，一个管理核心A(领导Shadel和Adams)，一个衰老和癌症的小鼠模型核心 B(首席博士亚历山德拉·萨科，SBP)和一个关于衰老和癌症的综合生物信息学核心C(首席博士。 索尔克研究所的Maxim Shokhirev)。卡奇、冯、萨科和肖克列夫都是非常有成就的科学家和 非常有资格领导他们的组成部分，并为PPG的全面领导做出贡献。这个6人组 执行团队将指导这个管理核心的具体目标。任务将由专门的 P01的行政协调员。作出决定的最终责任将是共同责任。 沙德尔和亚当斯，如多个PD/PI领导计划所述。 该行政核心的具体目标如下。 具体目标1.促进P01研究目标的实现。具体地说，核心A将提供设施 向项目和核心提供资源；促进培训；安排会议和年度现场务虚会；安排 EAB会议；进行项目和核心评估；必要时倡导项目和核心。 具体目标2.促进P01内外的互动和协作具体而言，核心A将 促进项目和核心之间的互动和协作；促进项目之间的资源共享 和核心；向广大科学界展示P01的外在面貌。 具体目标3.确保P01的合规性具体而言，核心A将负责财务 管理；遵守管制，包括老鼠和人体组织的使用；及时提交进展情况 报告；数据和资源共享；知识产权保护。

PROJECT SUMMARY – CORE A The overall goals of this PPG are to define the mechanisms that lead to increased incidence of hepatocellular carcinoma (HCC) with age and to leverage this understanding to develop and validate candidate approaches for enhanced early detection and prevention. To achieve these Goals requires an interdisciplinary team of experts, specializing in different molecular and cellular aspects of both cancer and aging biology, innovative mouse models and experimental tools, and Core facilities to maximize efficiencies and promote synergies. In turn, this multi-pronged team requires an Administrative Core to support and orchestrate its activities. Profs. Peter D. Adams (Sanford Burnham Prebys Medical Discovery Institute (SBP), La Jolla) and Gerald S. Shadel (Salk Institute, La Jolla) will serve as multiple PD/PIs, with Adams serving as the Contact PI. Shadel will lead Project 1 and Adams Project 2. Other Project Leads are Prof. Susan Kaech (Salk Institute, La Jolla; Project 3) and Prof. Gen-Sheng Feng (University of California, San Diego (UCSD); Project 4). The P01 also incorporates three Cores, an Administrative Core A (Leads Shadel and Adams), a Mouse models of aging and cancer Core B (Lead Dr. Alessandra Sacco, SBP) and an Integrated bioinformatics of aging and cancer Core C (Lead Dr. Maxim Shokhirev, Salk Institute). Kaech, Feng, Sacco and Shokhirev are all very accomplished scientists and highly qualified to lead their components and to contribute to overall leadership of the PPG. This 6-member Executive Team will direct the Specific Aims of this Administrative Core. Tasks will be executed by a dedicated Administrative Coordinator for the P01. Ultimate responsibility for making decisions will be the joint responsibility of Shadel and Adams, as outlined in the Multiple PD/PI Leadership Plan. The Specific Aims of this Administrative Core are as follows. Specific Aim 1. Facilitate the research Objectives of the P01. Specifically, Core A will make available facilities and resources to projects and cores; facilitate training; arrange meetings and annual on-site retreat; arrange EAB meetings; conduct Project and Core evaluation; advocate for Projects and Cores, as necessary. Specific Aim 2. Facilitate interactions and collaborations within and external to the P01 Specifically, Core A will facilitate interactions and collaborations between projects and cores; promote resource sharing between projects and cores; present the external face of P01 to the scientific community at large. Specific Aim 3. Ensure regulatory compliance of the P01 Specifically, Core A will be responsible for fiscal management; regulatory compliance, including mice and use of human tissues; timely submission of progress reports; data and resource sharing; protection of intellectual property.