Administrative Core

项目总结_核心A 病毒性肺炎的康复是一个临床上重要但尚未得到充分研究的过程。重症病毒性肺炎 对甲型流感病毒(IAV)或严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的病原体 冠状病毒病2019年(新冠肺炎)，损害下呼吸道导致急性呼吸窘迫 综合征(ARDS)。虽然急性低氧性呼吸衰竭是ARDS患者的一个决定性的临床特征， 支持性护理的进步使大多数患者能够挺过疾病的缺氧期。因此， 绝大多数ARDS患者死于多器官功能障碍，包括持续性呼吸衰竭， 在最初感染几天到几周后。除了避免额外的肺损伤外，通过低潮气量 呼吸机和其他几种支持性疗法，目前还没有针对病毒性肝炎患者的特效疗法 肺炎/ARDS。这种PPG的一个中心假设是呼吸衰竭的持续性和 ARDS患者多器官功能障碍的发展是正常功能衰竭的结果 炎症消退和肺组织修复的机制。这一假说在临床上得到了最近一项研究的支持 ARDSNet中ARDS患者的“高炎性”内型患者的分析 与不良的临床结果有关，包括死亡。我们建议调查恢复的过程 来自病毒性肺炎，重点是促进肺部炎症和 肺损伤的健康修复。核心A将协助PPG调查人员测试这一核心假设 这一PPG通过一系列高度集成和创新的实验，专注于五个具体目标： 具体目标1.支持项目调查人员、核心领导之间的沟通，协作 调查人员以及内部和外部咨询委员会成员。 具体目标2.为各国之间分享材料和传播信息提供一个结构 项目调查员、核心领导及其合作者。 具体目标3.向项目和核心领导提供财务和监管监督，并协调 他们与机构核心服务的互动。 具体目标4.通过出版物传播方案项目调查人员的发现， 向其他机构和其他调查人员介绍和分享资源。 具体目标5.为培养学生跨学科协作研究和辅导的环境， 博士后研究员和研究人员。

PROJECT SUMMARY_CORE A Recovery from viral pneumonia is a clinically important yet understudied process. Severe viral pneumonia due to influenza A virus (IAV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), damages the lower respiratory tract to cause acute respiratory distress syndrome (ARDS). While acute hypoxemic respiratory failure is a defining clinical feature in patients with ARDS, advances in supportive care allow most patients to survive the hypoxemic phase of their illness. As a result, the vast majority of patients with ARDS die from multiple organ dysfunction, including persistent respiratory failure, days to weeks after the initial infection. Other than avoidance of additional lung injury, via low tidal volume ventilation and a handful of other supportive therapies, there are no specific therapies for patients with viral pneumonia/ARDS. A central hypothesis of this PPG is that the persistence of respiratory failure and the development of multiple organ dysfunction in patients with ARDS is a consequence of the failure of normal mechanisms of inflammation resolution and lung tissue repair. This hypothesis is clinically supported by a recent analysis of patients enrolled in the ARDSnet where a “hyperinflammatory” endotype of ARDS patients was associated with poor clinical outcomes, including death. We propose to investigate the process of recovery from viral pneumonia with a focus on mechanisms that promote resolution of lung inflammation and healthy repair of lung damage. Core A will assist the PPG investigators as they test this central hypothesis of this PPG through a highly integrated and innovative set of experiments by focusing on five Specific Aims: Specific Aim 1. To support communication between the Project Investigators, the Core Leaders, Collaborating investigators, and the Internal and External Advisory Committee members. Specific Aim 2. To provide a structure for the sharing of materials and dissemination of information between the Project Investigators, Core Leaders and their Collaborators. Specific Aim 3. To provide financial and regulatory oversight to the Project and Core Leaders and coordinate their interactions with Institutional Core Services. Specific Aim 4. To disseminate the discoveries made by the program project investigators through publications, presentations and the sharing of resources to other institutions and other investigators. Specific Aim 5. To foster an environment of collaborative interdisciplinary research and mentoring of students, post-doctoral fellows and investigators.