Administrative Core

总结 第二阶段行政核心的目标是继续集中和管理必要的资源， 增强COBRE在宿主-病原体相互作用（HPI）方面的成功。在第一阶段成功的基础上， 该核心将为致力于确定免疫机制的研究人员提供支持 在与各种微生物相互作用后，宿主中的调节，以确定可能的治疗破坏性 炎症性疾病。具体而言，协调一致的努力将集中在（1）扩大研究企业， 该中心通过支持和招募初级研究人员从事宿主-微生物相互作用， （2）通过组织网络，促进富有成效的科学互动 通过年度研讨会和系列研讨会提供机会;（3）提供个性化和量身定制的 为每个调查员提供指导计划; 4）通过以下方式为指导计划提供监督和支持 内部和外部咨询委员会，定期举行会议; 5）通过以下方式提高集团的国家形象： 提供最先进的基础设施支持; 6）建立一个新的计算数据分析核心设施， 为小组提供尖端的生物信息学分析和解释支持; 6）提供行政管理 支持现有核心（组织学、成像和流式细胞术）; 7）促进 其他北达科他州COBRE，INBRE和CTR DaCCoTA赠款支持团体和个人之间， 各自的群体。在我们的COBRE第2阶段成功完成这些目标将使该中心提升到 一个国家认可的水平，一个致力于了解宿主微生物各个方面的小组 人类健康和疾病的相互作用。随着最近对第二阶段表观遗传学COBRE和第三阶段的资助， I临床转化研究中心DaCCoTA，我们的HPI COBRE 2期有一个前所未有的机会 随时准备执行具有巨大治疗和临床潜力的高质量尖端研究。

Summary The goal of Administrative Core in Phase 2 is to continue centralizing and managing resources necessary to enhance the success of the COBRE on Host-pathogen Interactions (HPI). Building on the success of Phase 1, this Core will provide support to investigators focused on determining the mechanisms underlying immune modulations in the host upon interaction with various microbes to identify possible treatments for devastating inflammatory diseases. Specifically, the concerted effort will focus on (1) expanding the research enterprise of this center by supporting and recruiting junior investigators working on host-microbe interactions that are central to human health and diseases; (2) facilitating productive scientific interactions by organizing networking opportunities through annual symposium and seminar series ; (3) providing an individualized and tailored mentoring program for each investigator; 4) providing oversight and support for mentoring programs through Internal and External Advisory Committees with regular meetings; 5) raising the national profile of the group by providing cutting edge infrastructural support; 6) establishing a new Computational Data Analysis Core facility to provide cutting-edge bioinformatics analytical and interpretative support for the group; 6) providing administrative support to the existing Cores (Histology, Imaging and Flow Cytometry; and 7) fostering collaboration between the other North Dakota COBRE, INBRE and CTR DaCCoTA grant supported groups and between individuals in the respective groups. Successful completion of these goals in Phase 2 of our COBRE will elevate this center to a nationally recognized level with a group dedicated to understanding various aspects of host-microbe interactions in human health and disease. With the recent funding of a Phase 2 Epigenetics COBRE and a Phase I Clinical Translational Research Center DaCCoTA, our HPI COBRE Phase 2 has an unprecedented opportunity at hand to execute high-quality, cutting edge research of immense therapeutic and clinical potential.