Impact of sensorimotor pathway integrity on hand motor recovery in stroke survivors

项目摘要/摘要 家长资助(R01 HD094731)的目标是确定是否将TheraBraclet与手工作业相结合 对于中风后手功能的充分恢复，练习优于单纯的手作业练习 动力研究。家长资助的重点是确定TheraBraclet对手功能恢复的影响， 感觉马达握力控制和神经通讯。这一多样性补充将提供一个新的洞察力 感觉运动通路的完整性如何解释个体患者的手功能恢复。具体地说，三个 将检查感觉运动通路的完整性，包括感觉通路、感觉运动整合和 运动通路，作为神经交流评估的一部分进行测量。这份副刊有两份 目标。目的1：确定三种感觉运动通路的完整性对运动恢复的影响。它是 假设感觉运动通路的所有三个组成部分在基线时的完整性将 独立参与上肢康复干预有助于运动功能恢复的程度。目标2： 运动恢复时测定三条感觉运动通路的神经可塑性。它被假设为 感觉运动通路的三个组成部分的完整性将从前肢到后肢得到改善 康复干预。影响：这项多样性补充研究将阐明 除考虑运动通路的完整性外，还应考虑感觉通路和感觉运动的整合。 卒中运动恢复预后(目标1)和神经可塑性(目标2)。对所有神经通路的思考 与感觉运动控制相关的，而不仅仅是运动途径，预计会改善预后 中风后的运动恢复。此外，感觉运动中发生的变化的完整图景 通路有望阐明运动恢复的神经机制。最重要的是，这个奖项将 培养有弱势背景的候选人(珍娜·布拉施克女士)成为OTD/博士研究员。这个 培训活动将侧重于为Blaschke女士开发新的研究技能，以执行补编 研究并开始她的研究生涯。具体地说，Blaschke先生将(1)提高对 神经康复研究领域，(2)熟练地对脑电进行量化、分析和解释，并 TMS用于感觉、感觉运动整合和运动通路完整性及其与运动恢复的关系 和(3)促进她的专业发展，包括传播，格兰特精神，发展一个 博士学位申请成功。来自该补充奖的培训将构成 她未来的职业是临床研究人员，以改善中风后的运动恢复并使生物医学多样化 劳动力。

PROJECT SUMMARY / ABSTRACT The objective of the parent grant (R01 HD094731) is to determine if combining TheraBracelet with hand task practice is superior to hand task practice alone for recovery of hand function post-stroke in an adequately powered study. The parent grant focuses on determining the effect of TheraBracelet on hand functional recovery, sensorimotor grip control, and neural communication. This diversity supplement will provide a new insight into how sensorimotor pathway integrities explain individual patients’ hand functional recovery. Specifically, three sensorimotor pathway integrities will be examined including the sensory pathway, sensorimotor integration, and motor pathway, all measured as part of the assessment for neural communication. This supplement has two aims. Aim 1: Determine the effects of the three sensorimotor pathway integrities on motor recovery. It is hypothesized that the integrity of all three components of the sensorimotor pathways at baseline will independently contribute to the extent of motor recovery with upper extremity rehabilitation intervention. Aim 2: Determine neuroplasticity of the three sensorimotor pathways with motor recovery. It is hypothesized that the integrity of the three components of the sensorimotor pathways will improve from pre to post upper extremity rehabilitation intervention. Impact: This diversity supplement research will elucidate the importance of considering the sensory pathway and sensorimotor integration in addition to the motor pathway integrity for post- stroke motor recovery prognosis (Aim 1) and neuroplasticity (Aim 2). Consideration of all neural pathways associated with sensorimotor control, rather than just the motor pathway, is expected to enhance prognosis of motor recovery following stroke. In addition, the complete picture of the changes occurring in the sensorimotor pathways is expected to elucidate the neural mechanisms of motor recovery. Most importantly, this award will foster the candidate with a disadvantaged background (Ms. Jenna Blaschke) as an OTD/PhD researcher. The training activities will focus on developing new research skills for Ms. Blaschke to perform the supplement research and begin her research career. Specifically, Mr. Blaschke will (1) enhance the overall knowledge of the neurorehabilitation research field, (2) develop proficiency in quantifying, analyzing, and interpreting EEG and TMS for sensory, sensorimotor integration, and motor pathway integrities and their relations to motor recovery, and (3) advance her professional development including dissemination, grantsmanship, development of a successful application for a PhD program. The training from this supplement award will form the foundation for her future career as a clinician researcher to improve post-stroke motor recovery and diversify biomedical workforce.