Novel pathomechanisms and therapeutic approaches in Alzheimer's disease and related dementias

目前，超过20万澳大利亚人患有阿尔茨海默病（AD）或额颞叶变性（FTLD），造成了巨大的社会经济损失。为了克服缺乏有效的治疗方法，我们需要了解其根本原因并将其转化为治疗方法。利用最先进的细胞培养和基因小鼠模型，我将揭示阿尔茨海默病和相关痴呆的基本过程，并开发量身定制的治疗方法来对抗这些毁灭性的疾病。

Currently, over 200,000 Australians are affected by Alzheimer's disease (AD) or frontotemporal lobar degeneration (FTLD), causing a huge socio-economic damage. To overcome the lack of effective treatments, we need to understand the underlying causes and translate them into therapy. Using state-of-the-art cell culture and genetic mouse models, I will reveal fundamental processes in AD and related dementias, and develop tailored treatments to battle these devastating disorders.