Neurobiology of CNS Injury and Repair

项目摘要 这是一份续签申请，请求继续为中枢神经系统损伤和修复T32神经生物学提供资金 培训计划，每年支持4名博士前研究员，为期2年，致力于 具有创伤性脑损伤(TBI)、脊髓损伤(SCI)或中风领域的博士学位。总目标 继续为积极进取的研究生在神经创伤相关研究领域的职业生涯做准备 通过在脑损伤、脊髓损伤和中风的病理生理学方面提供广泛的基础培训，以及识别 潜在的疾病修饰分子靶点，可以推动药理学或基于基因的发现 治疗策略。执行委员会将从一批合格的申请者中挑选受训人员， 一般在博士生培训的第三年。学员将接受密集的实践研究指导，包括 重视教师实验室对量化评估工具的理解和运用 在部门中被任命。神经科学、生理学、分子和细胞生物化学及药学 通过与肯塔基大学(英国)的联系定期进行互动和合作的科学家 脊髓和脑损伤研究中心和高级翻译卒中科学中心(CATSS)。 除了课程工作，学员还将参加期刊俱乐部，负责进行研究培训， 中心和部门研讨会系列，以及一套定制的专业人员计划范围会议 技能和量化素养--实验设计和统计(PSQL-EDS)。每月的PSQL-EDS将 促进对量化素养、统计分析和科学严谨性等概念的主动学习，如 以及科学写作和职业发展。在被任命为T32计划的学生中 在过去的9年里，13人已经完成了博士学位，2人将在10年级完成博士学位，6人将继续他们的 博士培训。所有完成博士学位的人都继续从事与科学相关的工作。有几个是 继续他们的教育(3名博士后，1名住院医生)，一名是美国国立卫生研究院的AAAS科学政策研究员， 大多数人在学术界(3名助理教授、1名讲师、1名研究员)和生物医学领域从事职业 工业(2)。T32计划的博士学位完成和职业介绍的成功通过以下方式进一步突出 在招聘和留住多样化学员方面有出色的记录：很大比例的被任命者是 代表不足的种族或族裔，有残疾，或来自不利的背景。这个 计划的成功和持续发展将由两个小组指导：执行委员会由以下两个小组组成 在项目主任、培训学院和英国高级教师中，他们带来了管理专业知识， 指导和包容性研究倡议，以及由TBI、SCI、 和中风研究。通过将全面的、研究密集的培训与说教和 从不同的角度提供交互式教育/职业发展活动，这项T32计划是 独特的定位，以满足日益增长的对训练有素的科学家的需求，这些科学家渴望从事神经创伤方面的工作。

Project Summary This is a renewal application requesting continued funding for a Neurobiology of CNS Injury and Repair T32 Training Program to support 4 predoctoral fellows per year for a 2-year training period, working toward their PhD degrees in the fields of traumatic brain injury (TBI), spinal cord injury (SCI), or stroke. The overall goal continues to be to prepare highly motivated graduate students for careers in neurotrauma research-related fields by providing broad-based training in the pathophysiology of TBI, SCI, and stroke and the identification of potential disease-modifying molecular targets that can drive the discovery of pharmacological or gene-based therapeutic strategies. An Executive Committee will select trainees from a pool of qualified applicants, generally in their third year of PhD training. Trainees will receive intensive hands-on research mentoring, with an emphasis on understanding and applying quantitative assessment tools in laboratories of Training Faculty appointed in the Depts. of Neuroscience, Physiology, Molecular and Cellular Biochemistry, and Pharmaceutical Sciences who regularly interact and collaborate through their affiliation with the University of Kentucky's (UK) Spinal Cord & Brain Injury Research Center and Center for Advanced Translational Stroke Science (CATSS). In addition to coursework, trainees will engage in journal clubs, responsible conduct of research training, Center and Departmental seminar series, and a customized set of program-wide meetings in Professional Skills, and Quantitative Literacy-Experimental Design and Statistics (PSQL-EDS). The monthly PSQL-EDS will facilitate active learning of concepts such as quantitative literacy, statistical analysis, and scientific rigor, as well as scientific writing and professional development. Of the students appointed to the T32 Program in the previous 9 years, 13 have completed their PhDs, 2 will complete their PhDs in year 10, and 6 will continue their PhD training. All those that completed their PhDs continued into science-related positions. Several are continuing their education (3 postdocs, 1 resident), one is an AAAS science policy fellow at the NIH, and the majority are pursuing careers in academia (3 Assistant Professors, 1 instructor, 1 researcher) and biomedical industry (2). The PhD completion and career placement success of the T32 Program is further highlighted by an outstanding record of recruiting and retaining diverse trainees: a large proportion of appointees are of underrepresented race or ethnicity, have a disability, or come from disadvantaged backgrounds. The program's success and continued evolution will be guided by two groups: an Executive Committee comprised of the Program Directors, Training Faculty, and senior UK faculty who bring expertise in administration, mentoring, and inclusion research initiatives, and an External Advisory Board of national leaders in TBI, SCI, and stroke research. Through the pairing of comprehensive, research-intensive training with didactic and interactive educational/career development activities delivered from diverse perspectives, this T32 Program is uniquely positioned to fill a growing need for rigorously trained scientists who desire careers in neurotrauma.