REPOSITORY PULL FOR COLLABORATIVE PERINATAL PROJECT (CPP) OBESITY GENOME WIDE ASSOCIATION STUDIES (GWAS)

肥胖症是一种复杂的多因素疾病，由遗传易感性和生活方式因素如高能量食物消耗和身体活动不足引起。儿童BMI的遗传率估计为40- 70%。在当前致胖环境的背景下，肥胖症的高遗传性强烈表明，遗传因素与肥胖症的人群模式有关，正如我们在这里提出的，在解决肥胖症流行的人群方法中必须考虑遗传因素。 确定影响儿童早期BMI的遗传因素可以为肥胖的病因提供信息，并有助于确定预防和治疗儿童肥胖和相关成人心脏代谢疾病的策略。目前，影响儿童早期BMI的遗传因素还不清楚。全基因组关联研究（GWAS）可以帮助识别这些遗传因素，并区分它们在不同年龄段的影响。 围产期合作项目（CPP）是一项前瞻性妊娠队列研究，招募了1959-1965年在美国12个医疗中心接受产前护理的妇女。从怀孕早期开始对妇女进行跟踪，并从出生到7岁对她们的后代进行监测。虽然CPP在美国肥胖流行和致肥胖生活方式之前招募儿童，但使用该队列发现的遗传因素与最近的环境修饰剂之间的任何潜在相互作用都可以使用其他最近的队列进行验证。CPP提供了发现与非洲人和欧洲人肥胖相关的新遗传基因座的机会，并改善了欧洲人群中发现的已知基因座的功能特征。

Obesity is a complex multi-factorial condition that results from genetic predisposition and lifestyle factors such as high energy food consumption and physical inactivity. The heritability of childhood BMI has been estimated to be 40-70%. The high heritability of obesity in the context of the current obesogenic environment strongly suggests that genetic factors are implicated in population patterns of obesity and, as we propose here, are essential to consider in population approaches to address the obesity epidemic. Identifying genetic factors that influence early childhood BMI can inform the etiology of obesity as well as help to identify strategies to prevent and treat childhood obesity and related adult cardiometabolic diseases. Currently, the genetic factors that influence early childhood BMI are not well understood. Genome-wide association studies (GWAS) could help identify these genetic factors and distinguish their effects across ages. The Collaborative Perinatal Project (CPP) was a prospective pregnancy cohort that enrolled women who had prenatal care at 12 medical centers in the United States from 1959-1965. Women were followed from early pregnancy onwards and their offspring were monitored from birth through 7 years of age. While the CPP enrolled children prior to the obesity epidemic and obesogenic lifestyle in the United States, any potential interactions between genetic factors discovered using this cohort and recent environmental modifiers can be validated using other more recent cohorts. The CPP offers opportunities to discover novel genetic loci related to obesity among Africans and Europeans and to improve the functional characterization of known loci discovered in European populations.