Facility and Building System Upgrades Support for the Howard T. Ricketts Biocontainment Laboratory

项目摘要/摘要 霍华德·泰勒·里基茨实验室(HTRL)是一个最先进的地区 杜佩奇阿贡国家实验室(ANL)园区的生物遏制实验室 伊利诺伊州的县。位于芝加哥大学校区西南25英里处， ANL是一个联邦(能源部)拥有的网站，由芝加哥大学运营 (UChicago LLC)。HTRL是由芝加哥大学拥有的CDC认证机构， 由微生物系操作。生物安全培训和监测计划 参与课堂和实验室活动确保员工、学生和研究员遵守 根据州和联邦法规安全运行RG2、RG3的设施和实验 并选择代理病原体。高铁的建设于2008年完成。在过去13年中 多年来，HTRL一直在主持研究耶尔森氏菌的研究项目， 布鲁氏菌、柯克斯氏菌、立克次体、芽孢杆菌、耐甲氧西林金黄色葡萄球菌等ESKAPE生物以及病毒 病原体包括低致病性和高致病性流感、登革热和最近的SARS- CoV2。该设施目前拥有关于鼠疫、炭疽、MRSA的研究计划，以及一个 SARS-CoV2核心研究机构。HTRL是世界上最大的A-BSL3持有设施 并定期支持包括UIC、西北大学在内的财团机构的研究 HTRL正在实现其快速响应研究需求和支持的目标 对新出现和重新出现的病原体的生物医学查询，新的发现和测试 治疗学和疫苗。大楼一直处于良好的工作状态， 自建造以来一直在不断使用。然而，随着BSL3的膨胀需求， 和ABSL3空间的研究专长，开发新技术进行研究 感染性因素，本提案要求(I)升级系统和建筑组件 安全的研究操作，以及(Ii)更换使用寿命超过 预期使用寿命或不再满足设施要求。

Project Summary/Abstract The Howard Taylor Ricketts Laboratory (HTRL) is a state-of-the-art Regional Biocontainment Laboratory on the Argonne National Laboratory (ANL) campus in DuPage County, Illinois. Located twenty-five miles southwest from the University of Chicago campus, ANL is a federally (Department of Energy) owned site operated by the University of Chicago (UCHICAGO LLC). HTRL is a CDC certified facility owned by the University of Chicago and operated by the Department of Microbiology. Biosafety training and surveillance program involving classroom and laboratory activities ensures that staff, students, and fellows comply with state and federal regulations to safely operate facilities and experiments with RG2, RG3 and Select Agent pathogens. The HTRL construction was completed in 2008. Over the last 13 years, the HTRL has hosted research programs studying the bacterial species Yersinia, Brucella, Coxiella, Rickettsia, Bacilli, MRSA and other ESKAPE organisms, as well as viral pathogens including low and highly pathogenic influenza, DENGUE and more recently SARS- CoV2. The facility currently hosts research program on Plague, Anthrax, MRSA, as well as a Core Research Facility for SARS-CoV2. The HTRL is the largest A-BSL3 holding facility in the region and regularly supports research from consortium institutions including UIC, Northwestern U and Loyola U. The HTRL is fulfilling its goal to rapidly respond to research needs and support biomedical inquiries on emerging and re-emerging pathogens, discovery and testing of new therapeutics and vaccines. The building has been maintained in good working conditions and has been in constant use since its construction. However, with the swelling demands for BSL3 and ABSL3 space and research expertise, the development of new technologies for the study of infectious agents, this proposal is a request (i) to upgrade system and building components for safe research operations, and (ii) to replace research equipment that have either outlived the intended useful life or no longer meet facility requirements.