Administrative and Biostatistics Core

项目摘要--行政和生物统计核心 行政和生物统计核心(行政核心)的总体目标是促进研究工作，以 了解胰腺导管腺癌(PDA)患者对治疗的内在抵抗。这将是 通过提供三个研究项目(项目)和三个共享资源核心(核心)来实现 具有组织支持、专业的项目管理、生物统计专业知识、数据存储和共享 解决方案和治理框架。管理核心将计划和协调 科学团队之间，以及科学团队和领导班子之间。管理核心将包括 项目经理，将提供专业的项目管理服务，以确保所述目标 都是成功实现的。作为这项工作的一部分，项目经理将监督核心活动，以确保 这些尖端科学资源的努力是整合和协调的，核心正在运作 有效、高效地满足项目的需求。项目经理还将建立一个治理 解决团队成员之间潜在冲突和管理资源利用的框架 预算方面的担忧。管理核心将包括一个生物统计股，该股将密切参与所有 实验设计和数据分析。生物统计股将负责确保所有实验 都是足够强大的，所产生的数据是使用最科学的严谨的 接近了。当需要时，将开发新的方法。一名教职员工级别的统计员将平分他们的努力 在肿瘤和微环境中的生物统计单位和生物信息学团队之间 异构性核心，协调这些数据分析小组之间的通信和数据传输。 最后，管理核心将包括一名数据管理员，他将帮助建立和监督集中式数据存储 科学团队产生的所有数据都将被存入并作适当注释的系统。这 资源将促进不同数据集的整合以及数据和试剂的交换 酌情在项目、核心和外部研究界之间开展合作。因此，具体的目标是 行政核心的职责是：1)提供全面的组织支持，包括协调会议 在项目、核心和领导委员会之间，2)提供项目管理服务 确保以高效和具有成本效益的方式实现科学目标，3)提供生物统计学 确保实验的严密性和可重复性的专业知识，以及4)创建和管理集中式数据存储 和共享系统，实现数据集成。

PROJECT SUMMARY – Administrative and Biostatistics Core The overall goal of the Administrative and Biostatistics Core (Admin Core) is to facilitate research efforts toward understanding intrinsic resistance to therapy in pancreatic ductal adenocarcinoma (PDA). This will be accomplished by providing the three Research Projects (Projects) and the three Shared Resource Cores (Cores) with organizational support, professional project management, biostatistical expertise, data storage and sharing solutions, and a governance framework. The Admin Core will plan and coordinate meetings between the scientific teams, as well as between the scientific teams and the leadership groups. The Admin Core will include a Project Manager, who will provide professional project management services to ensure that stated objectives are successfully achieved. As part of this effort, the Project Manager will monitor Core activities to ensure that efforts of these cutting-edge scientific resources are integrated and coordinated, and that the Cores are operating effectively and efficiently to meet the needs of the Projects. The Project Manager will also establish a governance framework for resolving potential conflicts between team members and for managing resource utilization and budgetary concerns. The Admin Core will include a Biostatistics Unit that will be intimately involved in all experimental design and data analysis. The Biostatistics Unit will be responsible for ensuring that all experiments are sufficiently powered, and that the resulting data are analyzed using the most scientifically rigorous approaches. Novel methods will be developed when needed. One faculty-level statistician will split their effort between the Biostatics Unit and the bioinformatics team within the Tumor and Microenvironment Heterogeneity Core, coordinating communication and the transfer of data between these data analytic groups. Finally, the Admin Core will include a Data Curator who will help establish and oversee a centralized data-storage system into which all data generated by the scientific teams will be deposited and properly annotated. This resource will facilitate the integration of disparate datasets, as well as the exchange of data and reagents between the Projects, the Cores, and the external research community, as appropriate. Thus, the specific aims of the Admin Core are to: 1) provide overall organizational support including the coordination of meetings between the Projects, the Cores, and the leadership committees, 2) provide project management services to ensure that scientific objectives are achieved in an efficient and cost-effective manner, 3) provide biostatistical expertise to ensure experimental rigor and reproducibility, and 4) create and manage a centralized data storage and sharing system to enable data integration.