Core A - Administration

核心A摘要 行政核心。本计划项目的总体目标是阐明 异位钙化及其在衰老疾病的发病和病因学中的作用，特别关注年龄- 相关性黄斑变性（AMD）和阿尔茨海默病（AD）。异位妊娠的主要成分 钙化是蛋白质、脂质和矿化的磷酸钙，特别是羟基磷灰石（HAP）， 白磷钙石（WHT），但这些成分在钙化过程和疾病进展中的作用是 不知道。四个项目和一个技术核心将合作，以获得全面的机械观点， 异位钙化在年龄相关的病理。实现这一目标需要一个综合的多学科 方法，结合多尺度结构生物学，生物化学，细胞生物学和动物生理学，指导 这些特定领域的专家。行政核心的主要作用是确保 计划作为一个综合的多学科和多规模的调查工作，并产生一个全面的 老年疾病中钙化的观点，不能通过单独的实验室工作来实现。这 是获得全面生物医学见解的关键。为支持这一目标，核心将促进 调查人员之间的互动，并提供一个强有力的行政结构。

CORE A SUMMARY Administrative Core. The overall goal of this Program Project is to elucidate the biological mechanisms of ectopic calcification and its roles in the onset and etiology of diseases of aging, with particular focus on age- related macular degeneration (AMD) and Alzheimer’s disease (AD). The major components of ectopic calcifications are proteins, lipids and mineralized calcium phosphate, especially hydroxyapatite (HAP) and whitlockite (WHT), but the roles of these components in the calcification process and disease progression are not known. Four Projects and one technical Core will collaborate to gain a comprehensive mechanistic view of ectopic calcification in age-related pathologies. Achieving this goal requires an integrated multidisciplinary approach that combines multi-scale structural biology, biochemistry, cell biology and animal physiology, guided by experts in these specific areas. The principal role of the Administrative Core is to ensure the success of the Program as an integrated multidisciplinary and multi-scale investigative effort, and generate a comprehensive view of calcification in diseases of aging that could not achieved by individual laboratories working alone. This is essential for gaining comprehensive biomedical insights. To support this goal, the Core will facilitate interactions among the investigators and provide a strong administrative structure.