Membrane Protein Effectors of Pathogen Interactions With Host
病原体与宿主相互作用的膜蛋白效应子
基本信息
- 批准号:10404547
- 负责人:
- 金额:$ 25.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-06-01 至 2022-09-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAge related macular degenerationAlzheimer&aposs DiseaseBacterial Outer Membrane ProteinsBlood ProteinsCell AdhesionCell surfaceComplementDepositionDiagnosticDiseaseEnvironmentGoalsHealthHemostatic functionHost DefenseHumanImmunityKnowledgeLipidsMedical ResearchMembrane ProteinsNatural ImmunityPathogenesisPathologicPlayPreventiveProcessProteinsResearchResearch Project GrantsRoleStructureTechniquesTherapeuticYersinia pestisage relatedcell motilitydesigndrug developmentknowledge basemicrobialmultidisciplinarypathogenpathogenic bacteriapathogenic microbepublic health relevancerecruitsolid state nuclear magnetic resonancestressorstructural biologytargeted treatment
项目摘要
SUMMARY
Membrane protein effectors of pathogen interactions with host. The goal of this project is to develop a
framework for understanding the way in which the human host defenses interact with microbial pathogens and
age-related stressors. Many pathogens have evolved strategies to evade innate immunity by recruiting
complement regulatory factors onto the microbial cell surface. Moreover, the ectopic deposits that form in age-
related macular degeneration (AMD) and Alzheimer's disease (AD) are also rich in blood proteins involved in
innate immunity. Despite the biomedical importance of these processes, mechanistic knowledge is limited. This
research project is designed to address this knowledge gap. We focus on determining the structural basis for
two central interactions of human blood proteins involved in immunity, hemostasis and cell adhesion and cell
migration: (1) interactions with outer membrane proteins from the bacterial pathogen Yersinia pestis that are
important for pathogenesis, and (2) interactions with lipids and biominerals that are relevant to the formation of
pathological deposits associated with AMD and AD. Proteins in these highly heterogenous environments play
central roles in human health but are highly under-represented in the scientific knowledge base. We aim to bridge
this fundamental knowledge gap. Addressing these problems is important for advancing comprehensive
knowledge of the disease process and for developing diagnostic, preventive, and therapeutic approaches. The
research strategy is multidisciplinary. It relies significantly on structural biology techniques, particularly solution
NMR and solid-state NMR.
1
摘要
病原菌与寄主相互作用的膜蛋白效应因子。这个项目的目标是开发一种
了解人类宿主防御与微生物病原体和
年龄相关的压力源。许多病原体已经进化出一种策略,通过招募
补充微生物细胞表面的调节因子。此外,在年代中形成的异位沉积-
相关性黄斑变性(AMD)和阿尔茨海默病(AD)也富含血液蛋白质,参与
先天免疫力。尽管这些过程在生物医学上很重要,但机械知识是有限的。这
研究项目就是为了解决这一知识差距而设计的。我们的重点是确定
人血蛋白参与免疫的两种中枢相互作用:止血、细胞黏附和细胞
迁移:(1)与来自细菌病原体鼠疫耶尔森氏菌的外膜蛋白相互作用
重要的致病机制,以及(2)与脂质和生物矿物质的相互作用,这与
与AMD和AD相关的病理性沉积。在这些高度异质的环境中,蛋白质扮演着
在人类健康中的核心作用,但在科学知识库中的代表性严重不足。我们的目标是架起桥梁
这一根本的知识鸿沟。解决这些问题,对于全面推进
了解疾病的过程,并开发诊断、预防和治疗方法。这个
研究策略是多学科的。它在很大程度上依赖于结构生物学技术,特别是溶液
核磁共振和固体核磁共振。
1
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Francesca M Marassi其他文献
Francesca M Marassi的其他文献
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{{ truncateString('Francesca M Marassi', 18)}}的其他基金
Molecular mechanisms of calcification: roles and opportunities in diseases of aging
钙化的分子机制:在衰老疾病中的作用和机会
- 批准号:
10628925 - 财政年份:2023
- 资助金额:
$ 25.45万 - 项目类别:
Membrane Protein Effectors of Pathogen Interactions With Host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
10630318 - 财政年份:2016
- 资助金额:
$ 25.45万 - 项目类别:
Membrane Protein Effectors of Pathogen Interactions With Host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
10207010 - 财政年份:2016
- 资助金额:
$ 25.45万 - 项目类别:
Membrane protein effectors of pathogen interactions with host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
9071833 - 财政年份:2016
- 资助金额:
$ 25.45万 - 项目类别:
Membrane Protein Effectors of Pathogen Interactions With Host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
10689583 - 财政年份:2016
- 资助金额:
$ 25.45万 - 项目类别:
Membrane protein effectors of pathogen interactions with host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
9276714 - 财政年份:2016
- 资助金额:
$ 25.45万 - 项目类别:
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