Cross-Species Multidisciplinary Training in Alcohol Research

这份修订后的申请书提出了一个新的T32机构国家研究服务奖，为期五年 支持资助酒精研究的跨物种多学科培训，包括四名博士前和 两名博士后实习生。弗吉尼亚联邦大学(VCU)在酒精方面有着卓越的历史 和药物滥用领域，在目前活跃的NIAAA奖(n=36)中，在全国排名第7。现有主要研究 或培训资金包括：NIDA或NIAAA目前资助的80个项目，NIAAA P50支持的VCU酒精 研究中心(VCU-ARC)，向VCU学员颁发12个个人F-奖(7个NIAAA，5个NIDA)，NIDA T32- 支持的培训计划目前已进入连续资助的第46个年头，NIMH T32培训计划为 20多年，以及最近资助的医学科学家培训计划T32。酒精的焦点 VCU的研究是VCU酒精研究中心(VCU-ARC)，目前已进入NIAAA支持的第12个年头 P50资金于2020年续期。VCU-ARC致力于跨物种遗传、基因组、 行为和分子研究，以确定基因、基因网络和遗传变异导致风险和 酒精使用障碍的机制(AUD)。VCU-ARC和VCU在酒精研究方面的整体卓越 为VCU的多个部门或机构提供一个良好的培训环境。其中包括： 弗吉尼亚精神病学和行为遗传学研究所(VIPBG)和药理学和 毒理学、人类和分子遗传学、心理学、精神病学、内科学和 神经科学。跨物种的学术范围将包括为期两年的每月酒精基础 研究讲座系列，每月在VCU ARC举行研究研讨会，VCU ARC是一个由学员领导的酒精研究期刊俱乐部， 严格的部门特定核心课程和高级选修课，在 导师包括论文委员会的互惠服务，多个优秀的研讨会系列，并要求 出席国内或国际酒精研究会议。多个积极的VCU计划将会增加 培训对象多样化，留住任职人数不足的少数族裔教员，加强导师培训。 具体的专业计划优势包括：i)教师在行为学方面的广泛的跨种族专业知识 药理学、精神病学、遗传学、神经科学、统计学、神经成像、数据科学和心理学；二) 高生产率的研究环境，拥有有成就的、资金充足的教师；iii)丰富的经验和 在这一级别的培训中，不同教员的良好记录；iv)获得大量信息丰富的数据集 在VCU收集；v)利用VCU的创新文本进行负责任的研究指导 该领域的专家；以及vi)VCU独特的氛围和良好的记录，以支持多样性 为此类努力提供多项资助的计划。因此，这一培训计划提供了广泛的、跨物种的 在研究卓越和尊重多样性的环境中进行酒精研究培训。

This revised application proposes a new T32 Institutional National Research Service Award with five years of support to fund Cross-Species Multidisciplinary Training in Alcohol Research, comprising four pre-doctoral and two postdoctoral trainees. Virginia Commonwealth University (VCU) has a history of excellence in the alcohol and drug abuse fields, ranking 7th nationally in currently active NIAAA awards (n=36). Major existing research or training funding include: 80 NIDA or NIAAA currently funded projects, NIAAA P50 supported VCU Alcohol Research Center (VCU-ARC), 12 individual F-awards to VCU trainees (7 NIAAA, 5 NIDA), NIDA T32- supported training program now in its 46th year of continuous funding, NIMH T32 training program funded for over 20 years, and a recently funded Medical Scientist Training Program T32. A focal point for alcohol research at VCU is the VCU Alcohol Research Center (VCU-ARC), now in its 12th year of NIAAA support with P50 funding renewed in 2020. VCU-ARC pursues an integrated cross-species program of genetic, genomic, behavioral and molecular studies to identify genes, gene networks and genetic variants contributing to risk and mechanisms of alcohol use disorder (AUD). VCU-ARC and the overall excellence in alcohol research at VCU make this a fertile training environment across multiple VCU departments or institutes. These include: the Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG) and the Departments of Pharmacology & Toxicology, Human and Molecular Genetics, Psychology, Psychiatry, Internal Medicine and the Program in Neuroscience. The cross-species academic scope will include a 2 year, monthly Foundations of Alcohol Research lecture series, monthly research seminars in VCU ARC, a trainee-led alcohol research journal club, rigorous departmental-specific core courses and advanced electives, a high level of collaboration among mentors to include reciprocal service on thesis committees, multiple excellent seminar series, and required attendance at national or international alcohol research meetings. Multiple active VCU initiatives will increase diversity of trainees, augment retention of under-represented minority faculty and enhance mentor training. Specific major program strengths include: i) broad cross-species expertise of faculty in behavioral pharmacology, psychiatry, genetics, neuroscience, statistics, neuroimaging, data science and psychology; ii) highly productive research environment with accomplished, well-funded faculty; iii) extensive experience and excellent track record of a diverse faculty in training at this level; iv) access to large, informative datasets collected at VCU; v) instruction in responsible conduct of research utilizing an innovative text from a VCU expert in this field; and vi) a unique atmosphere and strong track record at VCU for support of diversity with multiple funded programs for such efforts. This training program thus offers a broad-based, cross-species training in alcohol research in an environment of research excellence and respect for diversity.