Interdisciplinary Training in Auditory Neuroscience

项目总结/摘要 有一个国家的需要，以提高对听力的理解，在健康的病人和那些与各种 听力损失的原因，这有助于降低生活质量，并与更差的健康状况相关 结果。这个继续培训计划的目标是培养下一代教师谁将 科学、工程和健康科学学院的学生，以及将毕业生送到工业界的学生。 准备为治疗听力损失的创造性解决方案而努力。具体来说，为了提高听觉 神经科学培训，这个研究生培训计划利用教师的专业知识，在基础听力科学 来自普渡大学三个学院（科学，工程和健康与人类）的技术开发 科学）和8个博士招生计划。包括两类调查人员：10名听力科学家 与神经系统神经科学相关的重点研究项目，并培训了12名技术创新者 在其他学科中（例如，生物医学和电子工程、计算机科学）。集体和 通过合作，该计划扩展了有关分子，细胞和系统机制的知识 听觉信息处理的基础。这些基本知识可以更好地应用于 了解由于损伤，疾病，衰老导致听觉系统病理的变化， 先天性疾病，以及理解听力如何进化和影响行为和自然 选择.解决这些问题的技术方法包括但不限于超分辨率 显微镜，用于神经调节的生物植入物，高分辨率四维钙成像， 用于脑回路分析的哺乳动物大脑、光遗传学和机器人技术（自动膜片钳），以及 多模式脑成像方法，加上先进的统计和数据分析方法和模型 发展TPAN的独特之处在于，它是专门为学生提供本科学位， 生命科学、物理科学或工程学等不同学科，并将它们合并为一个统一的群体。 专注于听觉神经科学选出四名研究员，任期两年，领取培训补助金，从2009年1月1日开始。 第二年的开始。培训课程包括4门核心课程（神经科学、 听觉周边，中枢/行为听觉科学和信号处理），一个必要的赠款写作课程， 每周一次的听力科学研讨会系列，学生和教师出席，每年出席 校外培训课程和/或神经科学会议。纵向和横向指导提供 在各级提供培训和支持，加强科学网络，并培养所有人的集体意识 听力科学专业的学生（当前和最近的TPAN研究员，加上TPAN分支机构），促进在听力科学领域的成功。 PhD之后与普渡大学综合神经科学研究所合作， 为每名研究员配备一名数据管理咨询人，单独编列培训相关费用预算， 多样性招聘教师和学生，以及行政支持。

PROJECT SUMMARY/ABSTRACT There is a national need to advance the understanding of hearing in both healthy patients and those with various causes of hearing loss, which contribute to reduced quality of life and are correlated with much poorer health outcomes. The objective of this continuing training program is to train the next generation of faculty who will populate colleges of science, engineering, and health sciences, as well as to send graduates into industry prepared to work toward creative solutions for treating hearing loss. Specifically, in order to advance auditory neuroscience training, this graduate training program leverages faculty expertise in both basic hearing science and technology development, from three Purdue University colleges (Science, Engineering, and Health & Human Sciences) and 8 doctoral admissions programs. Two types of investigators are included: 10 hearing scientists with focused research programs related to auditory-system neuroscience, and 12 technology innovators trained in other disciplines (e.g., biomedical and electrical engineering, computer science). Collectively and collaboratively, the program expands knowledge about mechanisms at the molecular, cellular, and systems levels that underlie auditory information processing. This fundamental knowledge can then be applied to better understand the changes that lead to pathologies of the auditory system due to damage, disease, aging, and congenital disorders, as well as understanding how hearing evolved and influences behavior and natural selection. Technological approaches to these questions include, but are not limited to, super-resolution microscopy, biological implants for neuromodulation, high-resolution four-dimensional calcium imaging deep in the mammalian brain, optogenetics and robotics (automated patch-clamping) for brain circuit analysis, and multimodal brain imaging methods, coupled with advanced approaches in statistical and data analysis and model development. TPAN is unique in that it is specifically designed to serve students with undergraduate degrees in the disparate disciplines of life science, physical science or engineering, and merge them into a unified cohort focused on auditory neuroscience. Four fellows are selected for a 2-year term on the training grant, beginning at the start of their second year. The training curriculum includes 4 core courses (one each in neuroscience, the auditory periphery, central/behavioral auditory science, and signal processing), a required grant-writing course, a weekly Hearing Science seminar series where students and faculty present, and yearly attendance at extramural training courses and/or auditory-neuroscience conferences. Vertical and horizontal mentoring provide training and support at all levels, to enhance scientific networks, and to foster a sense of community among all hearing-science students (current and recent TPAN fellows, plus TPAN affiliates) that promotes success in the PhD and afterwards. Support is provided, in collaboration with Purdue's Institute for Integrative Neuroscience, for an individual data-management consultant for each Fellow, individually budgeted training-related expenses, diversity recruiting by both faculty and students, as well as for admininstrative support.