Development and Neuroadaptations in Alcohol and Addictions (DNA2)

这项提议的目标是在以下领域更新一个非常成功的博士后和博士后培训方案 酒精和成瘾的发育和神经适应(DNA2)。鉴于越来越多的人认识到酒精 使用障碍和其他成瘾根源于早期发展，拟议的培训补助金将 为下一代研究人员提供概念问题和方法论方面的重要培训 研究导致物质使用和使用障碍的发育神经适应的方法。建房 论这一领域现有的研究优势--以发展性暴露酒精研究为例 中心(DARC)，并以历史上强大的发展、成瘾和研究生培训计划为基础 和心理系内的神经适应，DNA2计划将提供丰富、合作的 有利于非常成功的研究培训、教学教育和指导的智力环境 对于拟培训的博士后(每年4次)和博士后(每年2次)。培训计划强调五个方面 主要目标：(1)积极寻找和招聘一批高素质和多样化的博士后和博士后 对酒精和成瘾研究感兴趣并致力于研究的学员(S)符合一个或多个实验室的要求 更多符合导师资格的教师，并为每位教师提供个性化的培训体验，以促进 精通最先进的评估、假设形成、严格的实验设计、数据获取 和分析，以及口头演示和发布结果；(2)创建正式的培训计划， 强调概念知识和技术能力的广度，并促进翻译 考虑因素；(3)强调21世纪科学家的批判性思维、科学严谨性和最佳实践 (4)支持每一位受训人员的事业/专业发展。为了实现这些目标，T32 该计划将通过授课课程、实习生研讨会、 研讨会/学术讨论会、期刊和写作俱乐部、受监督的研究经验以及参与 专业会议和校外培训机会。的方法论问题和技术 酒精和药物成瘾研究将在每一项为期两年的典型培训期间得到重视 受训人员，特别注重发展方法方面的培训，并严格关注#年的教育 负责任的研究行为，包括提高研究重现性的手段。这次培训 该计划将教职员工的专业知识与酒精领域和研究领域的成熟专业知识相结合 与其他成瘾药物一起，利用研究项目和视角的协同效应。

The goal of this proposal is to renew a highly successful pre- and post-doctoral training program in the area of development and neuroadaptations in alcohol and addictions (DNA2). Given increasing recognition that alcohol use disorder and other addictions have roots established in early development, the proposed training grant will provide the next generation of researchers with crucial training in the conceptual issues and methodological approaches for studying developmental neuroadaptations leading to substance use and use disorder. Building on existing research strengths in this area, exemplified by the Developmental Exposure Alcohol Research Center (DEARC), and anchored by historically strong graduate training programs in development, addictions and neuroadaptations within the Department of Psychology, the DNA2 program will provide a rich, cooperative intellectual environment conducive for highly successful research training, didactic education and mentorship for the proposed predoctoral (4/year) and postdoctoral (2/year) trainees. The training program emphasizes five key goals: (1) to actively seek and recruit a highly qualified and diverse group of pre- and post-doctoral trainees whose interest in and commitment to research in alcohol and addictions fits the laboratory(s) of one or more mentor-eligible faculty and to provide each with an individualized training experience that fosters expertise in state-of-the-art assessments, hypothesis formation, rigorous experimental design, data acquisition and analysis, and oral presentation and publication of results; (2) to create a formal training program that emphasizes breadth in conceptual knowledge and technical capabilities and fosters translational considerations; (3) to emphasize critical thinking, scientific rigor and best practices for scientists of the 21st century; and (4) to support the career/professional development of each trainee. To meet these goals, the T32 program will provide comprehensive interdisciplinary training through didactic coursework, trainee workshops, seminars/colloquia, journal and writing clubs, supervised research experiences, and participation in professional meetings and extra-university training opportunities. Methodological issues and techniques in alcohol and drug addiction research will be emphasized throughout the typical 2-year training period for each trainee, with a particular focus on training in developmental approaches, and rigorous attention to education in the responsible conduct of research, including means to enhance research reproducibility. This training program combines the expertise of faculty with established expertise in the alcohol field, as well as in research with other addictive drugs, to capitalize on synergies across research programs and perspectives.