Leveraging the Global Network to implement health interventions to improve maternal and child outcomes in a rapidly changing environment

项目总结 尽管最近取得了进展，但加快执行高效和可持续的公共卫生政策 将被要求实现可持续发展目标(SDG)的孕产妇和儿童健康目标 2030年。此应用程序的总体目标是继续参与与 全球网络(GN)的使命，旨在通过以下方式制定和测试潜在的可持续干预措施 协作性、大规模、高影响力的多站点通用研究协议。我们的主要目标是 代表科罗拉多大学和危地马拉之间合作伙伴关系的研究单位(RU)将 制定和测试干预措施，以减轻营养不良对母婴健康构成的优先威胁 在快速变化的环境背景下的感染。我们团队的具体研究专长是 营养、传染病和环境应激源的生物效应。这一目标将会实现 通过以下具体目标：1)继续并提高作为GN的强大研究记录和生产力 成员；2)通过高影响的临床试验和观察，继续开发通用的GN方案 对母婴健康具有变革性的研究；以及3)继续培育一个日益强大的 与我们在危地马拉和其他GN网站的同事和合作者进行研究合作。在过去 5年来，这所大学已经建立了强大的研究记录，超过60本GN出版物证明了这一点 (约40%由我们的团队领导)；通过完成纵向生长和神经发育跟踪 通过在四个地点进行2年的孕前孕妇营养干预试验，积极咨询 另外两项主要GN试验的儿童神经发育随访；加强了 危地马拉；成功执行GN发起的所有共同协议，包括新冠肺炎监控， 对每项研究的参与者数量和保留率的贡献较高；启动分析 为了证明母亲暴露在高温环境中对胎儿生长和分娩的不利影响 成果；获得外部资金，以支持共同议定书的执行。对以下方面的主要贡献 这个RU的GN包括在2个小组委员会中提供服务，以及联合担任 正在进行的孕产妇和新生儿健康登记处。我们继续参与GN的积极影响将是 通过利用我们在营养、传染病和环境方面的综合专业知识来实现 应激源设计干预措施，以改善孕产妇、婴儿和儿童的健康和在背景下的复原力 不断变化的环境。

PROJECT SUMMARY Despite recent progress, accelerated implementation of highly effective and sustainable public health policies will be required to meet the Sustainable Development Goals’ (SDG) targets for maternal and child health by 2030. The broad goal of this application is to continue to participate in all collaborative activities relevant to the mission of the Global Network (GN), which aims to develop and test potential sustainable interventions through collaborative, large-scale, high impact multi-site common research protocols. The primary objective of our research unit (RU), which represents a partnership between the University of Colorado and Guatemala, is to develop and test interventions to mitigate the priority threats to maternal-child health posed by malnutrition and infection in the context of the rapidly changing environment. The specific research expertise of our team is nutrition, infectious diseases, and biological effects of environmental stressors. This objective will be met through the following specific aims: 1) continue and enhance a strong research record and productivity as GN members; 2) continue to develop common GN protocols through high-impact clinical trials and observational studies that are transformative for maternal-child health; and 3) continue to foster a progressively stronger research partnership with our colleagues and collaborators in Guatemala and other GN sites. During the past 5-yr cycle, this RU has built a strong research record, evidenced by more than 60 GN publications (approximately 40% led by our team); by completion of longitudinal growth and neurodevelopment follow-up through 2 years in the four sites of the preconception maternal nutrition intervention trial; actively consulting on child neurodevelopmental follow-up for two other major GN trials; strengthened research capacity in Guatemala; successful implementation of all GN-initiated common protocols, including COVID-19 surveillance, with contribution of a high percentage of participant numbers and retention to each study; initiation of analyses to demonstrate adverse effects of maternal exposure to high ambient temperatures on fetal growth and birth outcomes; and securing external funding to support common protocol implementation. Major contributions to the GN by this RU include service on 2 subcommittees and co-chairing the oversight committee for the ongoing Maternal Newborn Health Registry. The positive impact of our continued participation in the GN will be accomplished by leveraging our combined expertise in nutrition, infectious diseases, and environmental stressors to design interventions to improve maternal, infant, and child health and resilience within the context of a changing environment.