Pacific Center for Genome Research

摘要 拟议中的夏威夷大学马诺阿分校太平洋基因组研究中心(PCGR)旨在 发展和支持UHM的基因组研究队伍，这是一个少数民族服务机构(MSI)，它有一个 在生物医学研究中为历史上代表性不足的人群提供服务的使命，即土著夏威夷人和 其他太平洋岛民。UHM授予健康职业和与以下领域相关的科学博士学位 健康。我们将支持一个多人调查、跨学科的团队来开发两个相互关联和高度相关的 创新的基因组研究项目，以及三个核心，即行政核心、基因组工作人员 发展核心和社区参与核心。我们的两个项目解决了基因组学中的关键问题 包括：方法开发；疾病基因组学；基因组数据科学和计算基因组学； 基因组学和健康公平。随着其科学目标的实现，拟议的UHM PCGR将大幅扩大 UHM的不同基因组科学家和研究人员可以进行创新的基因组研究 通过提供与研究相一致的教学、实践和研究活动和经验 项目。通过拟议的倡议，UHM的基因组研究能力将得到提高。力量和力量 基因组研究队伍的多样性和思想力将在所有职业级别得到加强 本科生、硕士和博士后、博士后研究员和初级教职员工。我们会 确定最有积极性的教员和早期调查人员，特别是来自代表性不足的人员 背景，对于从事基因组研究的职业。我们将物色资深教员加入指导团队 新的和早期的研究人员，并实施团队科学指导训练营，以实现个性化 教育和技能培训。我们将加强、巩固和维持基因组核心设施和资源 研究。我们将实施客观标准和衡量标准，以评估核心需求和使用情况，并核心- 依赖于研究生产力。通过引入新的研究人员和 将新的想法引入基因组学。代表性不足的人口和服务不足的社区的参与 体验健康差异(包括未得到充分研究的亚裔美国人、非裔美国人、西班牙裔/拉美裔美国人、 而且重要的是，将增加对土著夏威夷人和其他太平洋岛民的基因组研究。 机构投资将确保拟议的PCGR的可持续性，以提供基础设施和 在基因组研究科学方面取得卓越研究的新时代的资源。我们也感谢 有机会与本论坛资助的其他中心一起成为财团成员 与FPA相伴，并开发最佳实践和机会，以实现中心之间的协同。我们很高兴能 将我们在UHM中心积累的资源、数据和经验分享给其他MSI中心。

ABSTRACT The proposed Pacific Center for Genome Research (PCGR) at the University of Hawaii at Manoa (UHM) aims to grow and support Genomic Research workforce at UHM, a Minority Serving Institution (MSI), which has a mission to serve historically underrepresented population in biomedical research, namely, Native Hawaiians and other Pacific Islanders. UHM awards doctorate degrees in the health professions and the sciences related to health. We will support a multi-investigator, interdisciplinary team to develop two interrelated and highly innovative genomic research projects, along with three cores, namely, Administrative Core, Genomic Workforce Development Core, and Community Engagement Core. Our two projects address critical issues in genomics including: methods development; genomics of disease; genomic data science and computational genomics; and genomics and health equity. Along with its scientific goals, the proposed UHM PCGR will substantially expand the pool of diverse genomic scientists and researchers at UHM who can perform innovative genomics research by providing didactic, practicum and research activities and experiences that are aligned with the research projects. Through the proposed initiative, genomic research capacity will be increased in UHM. The strength and diversity of the genomics research workforce and thinkforce will be enhanced at all career levels of undergraduate students, master and PhD students, postdoctoral fellows, and junior faculty members. We will identify the most motivated faculty and early stage investigators, particularly those from underrepresented backgrounds, for careers in genome research. We will identify senior faculty to serve on mentoring teams for new and early-stage investigators, and implement a Team-Science Mentoring Bootcamp for personalized education and skills training. We will enhance, consolidate and sustain core facilities and resources for genome research. We will implement objective criteria and metrics to evaluate core needs and usage, and core- dependent research productivity. Innovation and creativity will be amplified by bringing new researchers and novel ideas into the genomics. Participation of underrepresented populations and underserved communities that experience health disparities (including understudied Asian Americans, African Americans, Hispanics/Latinos, and importantly, Native Hawaiians and other Pacific Islanders) will be increased in genomics research. Institutional investments will ensure the sustainability of the proposed PCGR to provide the infrastructure and resources for a new era of research excellence on the science of genome research. We also appreciate the opportunity to become a member of the consortium together with other Centers funded under this FOA and the companion FPA, and develop best practices and opportunities for synergy among Centers. We are excited to share resources, data, and experience we accumulate in our UHM Center to Centers of other MSIs.