Harvard School of Dental Medicine Collaborative Clinical Practice-based REsearch Program for DENTal Schools (H-CREDENT)

项目摘要/摘要 哈佛大学口腔医学院以合作临床实践为基础的研究项目 牙科学校(H-CREDENT)将启动一项创新的、以实践为基础的多学科研究计划 让牙科学生和住院医生与以研究和临床为基础的教师合作，以应对 牙科疼痛管理。H-CREDENT是HSDM、新英格兰大学、 马萨诸塞州药学与健康科学学院，梅哈里大学，查尔斯河社区健康 中心和剑桥健康联盟。该计划提供教学和实践的临床研究。 为博士后/博士后学生和临床/研究提供体验式学习/培训的机会 这些网站的教职员工。利用提供者/患者社区中独特的多样性，通过 通过这次合作，H-CREDENT致力于通过 进行以实践为基础的临床研究，以提高精确的口腔保健服务。 H-CREDENT将通过实现两个目标来努力实现这一目标：目标1：建立临床 研究技能发展计划，将在实践基础研究方面培训下一代临床学者 网络(PBRN)。技能发展将通过a)临床研究研究设计和 PBR，辅以b)独特的以豆荚为基础的体验式学习指导计划。课程将是 由HSDM调查人员与哈佛大学催化剂、国家PBRN和一家主要网络合作开发 拥有丰富临床研究经验的私人执业临床医生。课程将由H- 来自所有协作站点的CREDENT学员，每个导师舱将包括以研究/临床为重点的学员 来自所有机构的教师和博士前/博士后实习生，以促进牢固的导师关系，两者 跨机构的纵向(例如，学生/教员)和横向(例如，同行)。目标2：PBRN调查 与牙科学生和教师合作，确定侵入性疼痛的危险因素 牙科手术和根据人口统计、心理社会和遗传因素对患者进行分层。我们将a) 确定预测牙科手术后疼痛的风险因素，以及b)牙科提供者可以预测的准确程度 患者的疼痛经历和是否有偏差会影响这一预测，以及c)将患者确定为低/高风险 应用人工智能/机器学习通过患者分层发展术后疼痛 方法：研究方法。这项前瞻性的纵向研究将在所有地点进行，博士后/博士后学生将在那里 在患者临床导师的指导下，招募/注册，进行牙科手术，并对患者进行跟踪。 不同机构的H-CREDENT学员将通过指导豆荚分享不同的经历 整合和加强课堂上的学习，并直接参与临床研究。通过这些 活动，H-CREDENT将培养科学研究的文化，为有能力的牙科提供者做好准备 开展有效的实践性临床研究。

Project Summary/Abstract The Harvard School of Dental Medicine Collaborative Clinical Practice-based REsearch Program for DENTal Schools (H-CREDENT) will embark on an innovative, multidisciplinary practice-based research program to engage dental students and residents with research and clinical-based faculty to address the challenge of pain management in dentistry. H-CREDENT is a partnership amongst HSDM, University of New England, Massachusetts College of Pharmacy & Health Sciences, Meharry University, Charles River Community Health Center, and Cambridge Health Alliance. The program provides didactic and hands-on clinical research opportunities to deliver an experiential-learning/training for pre-/postdoctoral students and clinical/research faculty at these sites. Leveraging the unique diversity in the provider/patient communities brought together by this collaboration, H-CREDENT strives to prepare the next-generation oral healthcare providers through the conduct of practice-based clinical research to enhance precision oral healthcare delivery. H-CREDENT will work towards this goal by accomplishing 2 aims: Aim 1: Establishment of clinical research skills development program that will train next-generation clinical scholars in practice-based research networks (PBRNs). Skills development will be advanced via a) coursework in clinical research study design and PBR, complemented by b) unique pod-based mentorship program for experiential learning. Courses will be developed by HSDM investigators in partnership with Harvard Catalyst, national PBRN, and a premier network of private practice clinicians with extensive experience in clinical research. The courses will be taken by H- CREDENT trainees from all collaborating sites, and each mentoring pod will comprise research-/clinical-focused faculty and pre-/ postdoctoral trainees from all institutions to promote strong mentorship relationships, both vertically (e.g., student/faculty) and laterally (e.g., peer-peer) across institutions. Aim 2: A PBRN investigation to engage dental student and faculty providers to determine risk factors for developing pain following invasive dental procedures and stratify patients based on demographic, psychosocial, and genetic factors. We will a) determine risk factors predicting pain after dental procedures and b) how well the dental providers can predict the patients’ pain experience and if biases influence this prediction, and c) identify patients as low-/ high-risk for developing post-procedural pain through patient stratification by applying artificial intelligence/ machine learning methods. This prospective longitudinal study will take place at all sites, where pre-/postdoctoral students will recruit/enroll, perform dental procedures, and follow up with patients, under the guidance of their clinical mentor. Differential experiences by H-CREDENT trainees across institutions will be shared via mentoring pods to integrate and reinforce learnings from the classroom and direct participation in clinical research. Through these activities, H-CREDENT will foster a culture of scientific inquiry to prepare dental providers with aptitude for conducting effective practice-based clinical research.