Continuation of the NuMoM2b Heart Health Study

项目摘要/摘要 不良妊娠结局(APO)，包括妊娠高血压疾病、早产 出生，小于胎龄儿出生，和妊娠期糖尿病，与 母亲患心血管疾病的风险。这项未分娩妊娠结局研究： 监测准妈妈(NuMoM2B)在怀孕期间收集的生物样本和广泛的 2010-13年10,038名未分娩妇女的表型数据。NuMoM2B心脏健康 这项研究由7,003名nuMoM2B参与者组成，他们至少在之后重新联系了一次 他们出生的nuMoM2B，其中4,508人返回进行面对面的心血管疾病风险因素评估2-7 几年后。该队列目前处于第二阶段的随访中，并有多项辅助研究 并行运行，并在解决有关复杂相互作用的问题方面具有独特的地位 APOS和母体心血管疾病。不幸的是，该网络正面临几个与以下相关的挑战 新冠肺炎大流行的下游影响。我们提出了四项活动来解决这些问题 挑战、提高参与者参与度并扩展网络基础设施： ·加大参与者激励力度。之前增加的激励措施导致了改善 调查完成率。我们计划再增加一次，反映出重要的时间 我们研究参与者的投资和承诺。 ·增加学习网络支持。新冠肺炎大流行的下游影响 包括减少参与者对研究的参与度，并提高 错过学习访问，这增加了完成计划活动所需的时间。 提高对网络站点的支持水平将提高其应对 这些挑战和构建网络恢复能力。 ·开展远程访问试点研究。从最初的注册时间开始 NuMoM2B，约30%的研究参与者已经离开了他们的网络站点 并且不再位于允许他们亲自出席的旅行距离内 参观考察。我们建议完成一项远程访问的试点研究，使用国家 流动抽血员网络，以评估远程访问作为一种战略方法 保持这些参与者的参与度。 ·可持续的基础设施。为了进一步提高参与者参与度，该网络将 召开参与者参与委员会并扩展其在线信息 内容。此外，还将扩大对网络调查人员的分析支持，并 将准备发布最近收集的数据，以支持及时报告结果。

Project Summary/Abstract Adverse pregnancy outcomes (APO), including hypertensive disorders of pregnancy, preterm birth, small for gestational age birth, and gestational diabetes, are associated with cardiovascular disease (CVD) risk in mothers. The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be (nuMoM2b) collected biospecimens during pregnancy and extensive phenotyping data for 10,038 nulliparous women from 2010-13. The nuMoM2b Heart Health Study is comprised of 7,003 nuMoM2b participants who were recontacted at least once after their nuMoM2b birth, 4,508 of whom returned for an in-person CVD risk factor assessment 2-7 years later. This cohort is currently in a second phase of followup, with multiple ancillary studies running in parallel, and is uniquely positioned to address questions about the complex interplay of APOs and maternal CVD. Unfortunately, the network is facing several challenges related to the downstream effects of the COVID-19 pandemic. We propose four activities to address these challenges, improve participant engagement, and expand the network infrastructure: • Increasing participant incentives. Prior increases in incentives have resulted in improved rates of survey completion. We plan an additional increase, reflecting the significant time investment and commitment of our study participants. • Increasing study network support. Downstream effects of the COVID-19 pandemic include reduced participant engagement with research studies and increased rates of missed study visits, which increase the time required to complete planned activities. Increasing the level of support to network sites will improve their ability to respond to these challenges and build network resilience. • Implementing a pilot study of remote visits. Since the original time of enrollment in nuMoM2b, about 30% of study participants have moved away from their network sites and are no longer located within a travel distance that allows them to attend in-person study visits. We propose to complete a pilot study of remote visits using a national network of mobile phlebotomists to evaluate remote visits as a strategic approach to maintaining engagement of these participants. • Sustaining infrastructure. To further improve participant engagement, the network will convene a Participant Engagement Committee and expand its online informational content. In addition, analytic support to network investigators will be expanded and recently collected data will be prepared for release to support timely reporting of results.