Epidemiologic Field Studies

乳腺癌检测示范项目后续研究(01030)。这项研究跟踪了大约6万名乳腺癌示范项目(BCDDP)的前参与者。目前的分析包括各种队列财团汇集项目。胃癌：山东临衢市抑制胃癌前病变的随机多干预试验(00446)。我们收集了中国农村8年试验的15年随访数据，以确定三种治疗方法中的任何一种是否会影响胃癌的发病率或特定的死亡原因。这些治疗是从1995年到2003年长期补充维生素C、E和硒和大蒜，并于1995年一次性给予阿莫西林/奥美拉唑。2012年发表的一篇论文显示，阿莫西林/奥美拉唑治疗在15年内将胃癌发病率降低了39%。我们检查了亚组，并在研究开始时确定抗生素治疗对老年人群和患有晚期癌前病变的成员有效，尽管幽门螺杆菌被认为作用于胃癌发生的早期阶段。因此，抗生素治疗可以广泛应用于预防胃癌，而不需要局限于年轻人或那些组织病理学较轻的人。这部作品发表于2014年。炎症性乳腺癌病例对照研究(00314)这项病例对照研究包括北非5个中心(突尼斯1个，埃及2个，摩洛哥2个)发生的大约250例炎症性乳腺癌病例。两个对照组包括：1)250例非IBC乳腺癌病例；2)250名来访者对照(不包括一级亲属)，随机选择在研究医院住院的女性患者(不包括患有乳腺癌、卵巢癌、子宫内膜癌和鼻咽癌的患者)。这项研究涉及管理问卷、人体测量、唾液收集、IBC病例乳房的数字照片，以及IBC病例和非IBC乳腺癌对照的石蜡包埋肿瘤组织的收集。这项研究是与内布拉斯加州大学合作进行的，表格的开发和翻译由美国国家癌症研究所协调。NCI-DCEG负责在埃及、突尼斯和摩洛哥的研究中心制定研究程序。数据收集工作分别于2009年3月在埃及、2009年8月在突尼斯和2011年1月在摩洛哥开始。埃及和突尼斯的数据收集工作于2013年9月30日停止。该项目的数据收集工作将于2016年8月在摩洛哥结束。

BCDDP: Breast Cancer Detection Demonstration Project follow-up study (01030). This study follows about 60,000 former participants in the Breast Cancer Demonstration Project (BCDDP). Current analyses include a variety of cohort consortium pooling projects. Gastric cancer: Randomized multi-intervention trial to inhibit precancerous gastric lesions in Linqu, Shandong Province (00446). We gathered fifteen year follow-up data from an 8-year trial in rural China to determine whether any of three treatments would affect gastric cancer incidence or specific causes of mortality. The treatments were long-term vitamin (C, E, and selenium) supplementation and garlic supplementation, given from 1995 to 2003, and one time administration of amoxicillin/omeprazole given in 1995. A paper published in 2012 showed that amoxicillin/omeprazole treatment reduced gastric cancer incidence by 39% over a fifteen year period. We examined subgroups and determined that antibiotic treatment was effective for older members of the population and for members with advanced precancerous gastric lesions at the beginning of the study, despite the fact that Helicobacter pylori is thought to act on early stages of gastric carcinogenesis. Thus antibiotic treatment can be applied broadly to prevent gastric cancer and need not be restricted to the young or to those with mild histopathology. This work was published in 2014. Inflammatory breast cancer (IBC) case-control study (00314) This case-control study includes approximately 250 IBC cases accrued at 5 centers in North Africa (1 center in Tunisia, 2 in Egypt, and 2 in Morocco). Two control groups are being included: 1) 250 non-IBC breast cancer cases and; 2) 250 visitor controls (excluding first-degree relatives) to randomly selected female inpatients (excluding those with breast, ovarian, endometrial, and nasopharyngeal cancer) in the study hospitals. The study involves the administration of a questionnaire, anthropometric measurements, saliva collection, digital photographs of the breasts of IBC cases, and the collection of paraffin-embedded tumor tissue for IBC cases and non-IBC breast cancer controls. The study has been conducted as a collaboration with the University of Nebraska, with forms development and translation coordinated at the National Cancer Institute-USA. The NCI-DCEG is responsible for developing study procedures at the study centers in Egypt, Tunisia, and Morocco. Data collection began in March 2009 in Egypt, August 2009 in Tunisia, and January 2011 in Morocco. Data collection in Egypt and Tunisia stopped on 09/30/2013. Data collection for the project will end in Morocco by August 2016.