ENHANCED COLOR FLOW IMAGING OF BREAST CANCER

描述：（改编自研究者摘要） 本研究旨在提高对慢性乙型肝炎患者的诊断和管理水平， 乳腺癌通过发展和评估更有效 超声彩色血流成像和定量技术。 这 医学目标的实现是：1）进一步发展 用于获取、显示和量化血管分布的方法， 来自乳房超声的脉冲回波信息; 2）评估这些 超声诊断乳腺癌的方法和潜力; 3)在采购灵活性方面进行更长期的改进 和乳房超声成像的信息内容。 在过去几年里，在实现这些目标方面取得了重大进展。 01-03. 已经开发了用于显示复杂血管的方法， 灰度信息，以显示它们在3D中的关系， 量化在多普勒图像中提供给医生的内容。 的 引入功率模式成像作为医疗产品的动机是 通过我们的建议和工作的血液体积和灌注测量， 该项目的一部分，最初于1991年2月1日提出。 开发的3-D颜色的初步人体研究的数据采集 血流扫描、显示和定量接近完成。 初步分析表明，三维可视化是很有前途的 用于显示乳房区域的血管结构 肿块及其与可见时的脉冲回波病变的关系。 基于3D 血管分布的视觉评级有助于区分乳房 由灰度信息提供的癌症和归一化的，功率加权的， 多普勒信号像素密度判别效果较好。 拟 为了更好地表征测量结果， 并将人类研究延长1.5年，以增加 统计 少数恶性和良性病变将 在有和没有微泡造影剂的情况下研究， 局部晚期疾病，以评估三维彩色成像的预测价值 血流超声检测对全身化疗的反应。 非常有前途的初步演示多视图（复合）三维 乳房血流和其它结构的成像已经完成 通过从点的共配准的3-D图像集对准和解扭曲 以及在各种视图中手动找到的共同的线。 是 建议将这一令人兴奋的长期技术发展， 在04-06年通过计算机识别达到实用水平， 不同视图中的同源组织体积的配准。 到 便于在乳房周围任何位置采集3D图像集， 我们最近展示的基于图像的扫描位置 将制定登记办法。

DESCRIPTION: (Adapted from investigator's abstract) The objective of this study is to improve the diagnosis and management of patients with breast cancer through development and evaluation of more effective techniques for ultrasound color flow imaging and quantification. This medical objective is to be accomplished by: 1) further developing methods for acquisition, display and quantification of vascularity and pulse echo information from breast ultrasound; 2) evaluating these methods and the potential of ultrasound in discriminating breast cancer; 3) making more long range improvements in the acquisition flexibility and information content of ultrasound imaging of the breast. Significant advances were made toward each of these objectives in Years 01-03. Methods have been developed for displaying complex vascular and gray scale information to show their relationships in 3D and for quantifying what is offered to the physician in the Doppler images. The introduction of power mode imaging as a medical product was motivated by our proposal and work on blood volume and perfusion measurement as part of this project, which was proposed initially February 1, 1991. Data acquisition for initial human studies of the developed 3-D color flow scanning, display and quantification is nearly complete. Preliminary analyses indicate that 3-D visualization is quite promising for displaying the vascular architecture of the region of the breast mass and its relation to the pulse echo lesion when visible. 3D-based visual ratings of vascularity contributed to the discrimination of breast cancer provided by gray scale information and normalized, power-weighted, Doppler signal pixel density discriminated every better. It is proposed to better characterize the measurements, make the imaging more versatile and extend the human studies for an additional 1.5 years to increase the statistics. A small number of malignant and benign lesions will be studied with and without microbubble contrast as will a group with locally advanced disease to assess the predictive value of 3-D color flow ultrasound for response to systemic chemotherapy. Very promising preliminary demonstrations of multiview (compound) 3-D imaging of breast blood flow and other structures have been accomplished by 3-D image set alignment and unwarping from coregistration of points and lines found manually to be in common in the various views. It is proposed to bring this exciting long range development of technology to a practical level in years 04-06 by computerized identification and registration of homologous tissue volumes in the different views. To facilitate acquisition of 3-D image sets anywhere round the breast with many scanheads, our recently-demonstrated image-based scan position registration approach will be developed.