Age-Related Changes in Body Composition and Fuel Metabolism: The Role of Glucocorticoid Signalling in Osteoblasts

我们之前的研究表明，脂肪组织中与年龄相关的变化可能是由于骨形成细胞(成骨细胞)内糖皮质激素水平的增加。在成骨细胞中糖皮质激素水平选择性降低的小鼠，在年轻时与正常小鼠没有什么不同，但随着年龄的增长，可以防止肥胖和糖尿病的发生。这个项目将研究骨骼如何影响与年龄相关的脂肪质量的变化，并研究可能防止这种变化的方法。

Our previous studies suggest that age related changes in fat tissue could be due to an increased level of glucocorticoids within bone forming cells (osteoblasts). Mice in which the level of glucocorticoids in osteoblasts is selectively decreased were no different from normal mice at a young age but with ageing were protected against development of obesity and diabetes. This project will examine how bone influences age related changes in fat mass and examine ways in which this might be prevented.