SBIR TOPIC 401 PHASE II:

只要乳腺癌仍然是一个普遍的健康问题，对不断改进的乳腺癌成像和放射治疗技术的需求就会存在。设计变化——纳入新的硬件技术或方法——可能引发临床试验的需要，以确保安全性和评估性能。进行临床试验不仅费用昂贵，而且通常需要数年的时间来招募和研究患者。利用物理幻影，而不是病人，会更快，更便宜，减少病人的风险，并可能加快拯救生命的技术进步向公众提供的速度。目前，商业上可用的压缩和未压缩乳房模型不能产生真实的乳房图像；相反，它们提供了基本的乳房形状，没有解剖学信息。利用加州大学戴维斯分校的一个大型数据集（超过200个）三维真实患者乳房CT图像，以及一种新的phantom开发方法，我们建议填补这一需求。在这个二期SBIR项目中，我们将开发并商业化用于诊断和放射治疗应用的患者衍生的拟人化幽灵。我们还将研究我们的核心技术在开发用于前列腺、脑和肺成像应用的拟人化幻影方面的效用。

As long as breast cancer remains a pervasive health concern, the need for ever-improving breast cancer imaging and radiation therapy technologies will exist. Design changes – to incorporate new hardware technologies or methods - may trigger the need for clinical trials to ensure safety and assess performance. Conducting a clinical trial is not only expensive, but often takes years for patient recruitment and study. Utilizing physical phantoms, rather than patients, would be faster, far less expensive, reduces risk to patients and potentially increases the speed with which life-saving technological advances are made available to the public. Currently, commercially available compressed and uncompressed breast phantoms do not produce realistic breast images; rather they provide basic breast shapes with no anatomical information. Utilizing access to a large data set (over 200) of three-dimensional real patient breast CT images at UC Davis, and a novel approach to phantom development, we propose to fill this need. In this Phase II SBIR project, we will develop, and commercialize, patient-derived anthropomorphic phantoms for use in diagnostic and radiation therapy applications. We will also investigate the utility of our core technology in developing anthropomorphic phantoms for prostate, brain, and lung imaging applications.