NIDCD Core for Clinical Research and Care

NIDCD临床研究和护理核心支持以下NIDCD项目： 1 Zia DC000039综合征性和非综合征性耳聋基因鉴定 1 Zia DC000046人类沟通障碍的遗传学研究 1人遗传性耳聋的Zia DC000060分子分析 1 Zia DC000064听力和平衡障碍临床分析 1个ZIA-DC-000082神经病学项目 1-ZIA-DC-000088成人内耳听力恢复的细胞和分子机制 核心支持的NIDCD和协作协议包括： OH93-DC-0016-非综合征遗传性耳聋基因图谱：印度/巴基斯坦方案 97-DC-0180-遗传性耳聋的遗传分析 01-DC-0228-前庭导水管扩大所致听力障碍的临床和分子分析 01-DC-0229-遗传性听力和平衡障碍的遗传分析 12-DC-0152.听力前庭测试的标准值 17-DC-0138-顺铂和他汀类药物耳毒性 18-DC-0051-NIDCD生物检疫协议 20-DC-0047-遗传性听力损失的自然病史和基因组编辑 21-DC-0002-阿托伐他汀降低顺铂所致听力损失的III期干预研究 21-C-0009--儿童和成人嗅神经母细胞瘤的自然史研究 000077例头颈部疾病的临床资料和标本 000141听力不稳定表型 15-D-0129剂量递增研究评价单次注射携带人水通道蛋白-1基因的腺相关病毒载体治疗放射性腮腺功能减退的安全性 04C0165-CCR、NCI的数据收集、临床护理和干预 001572-贝伐珠单抗治疗成人复发性呼吸道乳头状瘤病的II期研究 21C0013：复发性呼吸道乳头状瘤病中的PRGN-2012 20C0024：头颈部鳞状细胞癌的新辅助IO 20C0104：联合免疫在口咽鳞状细胞癌中的表达 000462：天冬氨酸-1929年光免疫疗法 NIDCD临床研究和护理核心每年支持3000多个门诊评估。耳鼻咽喉科核心医生每年要做50-100例大手术。在高级临床助理期间，工作人员指导医学生。耳鼻喉科外科科学家职业发展计划是通过强迫症协调的。

The NIDCD Core for Clinical Research and Care supports the following NIDCD projects: 1 ZIA DC000039 Identification of Genes Causing Syndromic and Nonsyndromic Hearing Impairment 1 ZIA DC000046 Genetic Studies of Human Communications Disorders 1 ZIA DC000060 Molecular Analysis of Human Hereditary Deafness 1 ZIA DC000064 Clinical Analysis of Disorders Of Hearing And Balance 1 ZIA-DC-000082 Neurotology Program 1-ZIA-DC-000088 Cellular and Molecular Pathogenesis of Hearing Restoration in Adult Inner Ear The NIDCD and collaborative protocols supported by the core include: OH93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol 97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment 01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment with Enlarged Vestibular Aqueducts 01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance 12-DC-0152 - Normative values in audiovestibular testing 17-DC-0138 - Cisplatin and statins in ototoxcity 18-DC-0051 - NIDCD Biospecimens protocol 20-DC-0047 - Natural History and Genome Editing in Dominant Hearing Loss 21-DC-0002- Phase III Interventional Study using Atorvastatin to Reduce Cisplatin-Induced Hearing Loss 21-C-0009 - A Natural History Study of Children and Adults with Olfactory Neuroblastoma 000077 Clinical Data and Specimens in head and neck disorders 000141 Hearing Instability Phenotyping 15-D-0129 Dose-Escalation Study Evaluating the Safety of a Single Administration of an Adeno-Associated Virus Vector Encoding Human Aquaporin-1 in Irradiation-Induced Parotid Salivary Hypofunction 04C0165 - Data Collection, Clinical Care and Interventions in CCR, NCI 001572 - A Phase II Study of Bevacizumab in Adults with Recurrent Respiratory Papillomatosis (RRP) 21C0013: PRGN-2012 in Recurrent Respiratory Papillomatosis 20C0024: Neoadjuvant IO for head and neck squamous cell carcinoma 20C0104: Combo Immunotx in HPV oropharyngeal squamous cell carcinoma 000462: ASP-1929 Photoimmunotherapy The NIDCD Core for Clinical Research and Care supports over 3,000 outpatient clinic evaluations per year. Core otolaryngologists perform 50-100 major surgical cases annually. Staff mentor medical students during senior clinical clerkships. The Otolaryngologist Surgeon Scientist Career Development Program is coordinated through the OCD.