SPORE for Translational Approaches to Brain Cancer

总体：摘要 西北脑肿瘤孢子的总体目标是改善脑肿瘤的预后 患者在各种原发性脑内肿瘤中，胶质母细胞瘤（GBM）是最常见的。GBM 接受标准治疗的患者的中位生存期为20个月，5年生存期为20个月。 极其罕见为这种致命肿瘤开发更好治疗方法的进展令人失望。一个主要 这种缺乏治疗改进的原因是这种癌症所处器官的脆弱性质。 发生。对于GBM患者如何积极地进行手术治疗存在显著的局限性， 由于进入大脑的途径有限，系统性给药治疗的功效经常受到损害。到 为了解决与胶质母细胞瘤相关的公共卫生问题，我们组建了一支才华横溢的团队， 在脑肿瘤研究和治疗方面具有广泛背景的研究人员。这个团队的所有成员都有 表明成功指导自己的研究计划的专业记录。在一起，这些教师 发起了小组互动，以便将团队科学方法应用于研究和治疗 需要采取多学科办法，以取得有意义的进展。

OVERALL: SUMMARY The overall objective of the Northwestern Brain Tumor SPORE is to improve outcomes for brain tumor patients. Of the various primary intracerebral neoplasms, glioblastoma (GBM) is the most common. GBM patients that receive standard-of-care treatment have a median survival of 20 months, and 5-year survival is extremely rare. Progress in developing better treatments for this lethal tumor has been disappointing. A major contributor to this lack of therapeutic improvement is the delicate nature of the organ in which this cancer occurs. There are significant limitations to how aggressively GBM patients can be treated surgically, and the efficacy of systemically administered therapies are often compromised due to limited access to the brain. To address the public health problem that is associated with glioblastoma, we have assembled a talented team of investigators with extensive backgrounds in brain tumor research and therapy. All members of this team have professional records indicating success in directing their own programs of research. Together, these faculty initiated group interactions in order to bring a team science approach to bear upon the study and treatment of GBM, and for which a multidisciplinary approach is needed for achieving meaningful progress.