UW Comprehensive Cancer Center Support

项目摘要/摘要 威斯康星大学碳骨癌中心(UWCCC)寻求在49-53年间继续资助 进一步加快其使命，大幅减少其流域内外的癌症负担- 威斯康星州。UWCCC是威斯康星大学医学院内的矩阵中心 和公共卫生(SMPH)，由来自38个系和9个学院的218名教职员工组成 威斯康星大学麦迪逊分校(UW)。我们的成员通过6个月从事癌症护理、研究和教育。 科学计划(人类癌症病毒学、癌症遗传和表观遗传机制、肿瘤 微环境、成像和放射科学、发展治疗学、癌症预防和 控件)由12个共享资源提供支持。在当前赠款期间(2017-2021年)，领导层有 成功招募了40名更多样化的新成员，并加强了现有或新的基础设施 促进我们的会员出版3351篇与癌症相关的手稿(31%的方案间或方案内， 53%的机构间)，高(≥10)影响因子期刊的比例显著增加(先前拨款， 11%，而目前为23%)，增加了我们的NCI研究(直接2017年为1860万美元，2021年为2490万美元)和 研究资助(2017年直接资助7040万美元，2021年资助7630万美元)，获得更多多项目奖(P，U)，支持 更多的受训者和支持我们扩大集水区的社区。 UWCCC将通过培育一个多样化和支持性的癌症社区，可靠地完成这一使命 基础设施和高效资源。UWCCC致力于减轻我们流域的癌症负担 通过优先研究领域(例如，创新疗法和生物标记物、癌症成像和 扩大基于人群的癌症研究)、增强研究平台(例如，改进的临床研究 基础设施和共享资源)，加大努力建设与特派团有关的慈善事业，并扩大地方-- 全球合作伙伴关系。

PROJECT SUMMARY/ABSTRACT The University of Wisconsin Carbone Cancer Center (UWCCC) seeks continued funding for years 49-53 to further accelerate its mission to dramatically reduce the burden of cancer within and beyond its catchment – the State of Wisconsin. The UWCCC, which is a matrix center within the University of Wisconsin School of Medicine and Public Health (SMPH), is composed of 218 faculty members from 38 departments and 9 schools of the University of Wisconsin-Madison (UW). Our members pursue cancer care, research, and education through 6 scientific programs (Human Cancer Virology, Cancer Genetic and Epigenetic Mechanisms, Tumor Microenvironment, Imaging and Radiation Sciences, Developmental Therapeutics, and Cancer Prevention and Control) supported by 12 Shared Resources. During the current grant period (2017-2021), leadership has successfully recruited >40 new and more diverse members and strengthened existing or new infrastructure facilitating our membership publishing 3,351 cancer-relevant manuscripts (31% inter- or intra-programmatic, 53% inter-institutional) with a significant increased proportion in high (≥10) impact factor journals (prior grant, 11% compared to current 23%), increasing our NCI research (Direct 2017 $18.6M, 2021 $24.9M) and total research funding (Direct 2017 $70.4M, 2021 $76.3M), obtaining more multi-project awards (P, U), supporting more trainees and supporting communities throughout our expanded catchment. The UWCCC will accomplish this mission through nurturing a diverse and supportive cancer community, reliable infrastructure, and efficient resources. The UWCCC worked to decrease the burden of cancer in our catchment and beyond through prioritized research areas (e.g., innovative therapies and biomarkers, cancer imaging, and expanded population-based cancer research), enhanced research platforms (e.g., improved clinical research infrastructure and shared resources), increased efforts to build mission-related philanthropy, and expanded local- to-global partnerships.