VALIDATION AND EXPLORATION OF SLEEP AND MOOD PREDICTORS

报告的短睡眠和报告的长睡眠都是睡眠不足的主要预测因素。 过度的死亡风险，但报告的睡眠时间作为一种风险 因素尚不清楚。 睡眠相关的风险是特别感兴趣的， 妇女健康倡议（WHI），因为失眠增加妇女 在更年期，因为WHI的激素替代疗法（HRT）和 饮食调整（DM）可能会影响睡眠。 WHI将是一个令人兴奋的 有机会检查是否与报告的睡眠相关的风险 持续时间可以通过选择并发条件来解释，但是 广泛的WHI设计不能控制重要的潜在混杂因素。 明确地说，广泛的WHI设计本身不能确定， 行为可改变的客观睡眠持续时间是主要风险 因子 该辅助项目将补充WHI观察性研究 (OS)通过对600名圣地亚哥OS女性进行额外的检查。 这些志愿者将接受家庭睡眠记录，激素测量， 和详细的精神病访谈 为了便于区分 WHI结果中的情感和睡眠因素， OS子样本中的抑郁与睡眠量表的效度和信度 将对发给妇女健康倡议妇女的调查表中的项目i进行审查。 辅助 研究将确定客观记录的睡眠持续时间是否 死亡风险因素，睡眠时间是否可以区分 抑郁症作为WHI数据中的一个风险因素，以及睡眠相关风险是否 可归因于特定的病理生理过程， 呼吸暂停、昼夜节律相位提前、褪黑素缺乏，或 褪黑激素缺乏或生殖类固醇缺乏。

Both reported short sleep and reported long sleep are major predictors of excess mortality risk, but the import of reported sleep duration as a risk factor is not yet known. Sleep-related risks are of special interest to The Women's Health Initiative (WHI), because insomnia increases among women at menopause, and because WHI's hormone replacement therapy (HRT) and dietary modification (DM) may influence sleep. The WHI will be an exciting opportunity to examine whether risks associated with reported sleep durations can be explained by a selection of intercurrent conditions, but the broad WHI design will not control for important potential confounders. Explicitly, the broad WHI design by itself cannot determine if behaviorally-modifiable objective sleep durations are the primary risk factor. This ancillary project will supplement th WHI Observational Study (OS) by performing additional examinations on 600 San Diego OS women. These volunteers will undergo home sleep recordings, hormone measurement, and detailed psychiatric interviews. To facilitate distinction of affective and sleep factors in WHI outcomes, the types and severity of depression in the OS subsample and the validity and reliability of sleep items i questionnaires given to WHI women will be examined. The ancillary studies will determine whether objectively recorded sleep durations are mortality risk factors, whether sleep duration can be distinguished from depression as a risk factor in WHI data, and whether sleep-associated risks are attributable to specific pathophysiologic processes such as sleep apnea, circadian rhythm phase advances, deficiencies of melatonin, or deficiencies of melatonin, or deficiencies of reproductive steroids.