NEUROLOGY OF ATTENTION TO NOVEL EVENTS

以新奇为导向在引导注意力和 在正常个体中指导行为，并且在许多疾病中被破坏 states. 然而，人们对新奇感的神经基础知之甚少， 寻找 拟议的研究将调查神经解剖学和 对新刺激的反应的电生理学基础。 非脑 将对受损的受试者进行研究，以确定 关于CNS使用电生理记录对新刺激的反应 (as通过“新奇”P300测量）和信息的后续阶段 处理和行为反应（由受试者控制的 刺激暴露持续时间）。 将对中风患者进行研究， 研究局灶性病变对电生理和 新奇寻求的行为组成部分，并确定是否正面 皮层在这一活动中起着重要作用。 所有受试者将 研究在1）事件相关电位（ERP）实验室使用 专门设计的视觉刺激， 电生理反应和行为反应，以及2）眼睛 运动实验室使用视觉刺激引起探究性的眼睛 动作 中风患者将接受磁共振成像（MRI） 通过病变部位的三维表面重建， 描绘出结构性脑损伤的位置

Orienting to novelty plays a critical role in directing attention and guiding behavior in normal individuals and is disrupted in many disease states. Yet, little is known about the neural substrate of novelty seeking. The proposed research will investigate the neuroanatomical and electrophysiological underpinning of responses to novel stimuli. Non-brain damaged subjects will be studied to determine the link between early stages of C.N.S. responses to novel stimuli using electrophysiological recordings (as measured by the "novelty" P300) and subsequent stages of information processing and behavioral responses (as measured by subject-controlled stimulus exposure durations). Patients with strokes will be studied to investigate the impact of focal lesions on electrophysiological and behavioral components of novelty seeking and to determine if the frontal cortex plays an essential role in this activity. All subjects will be studied in 1) an Event-Related potential (ERP) Laboratory using specifically designed visual stimuli to evoke different electrophysiological responses and behavioral reactions and 2) an Eye movement Laboratory using visual stimuli to elicit exploratory eye movements. Stroke patients will undergo magnetic resonance imaging (MRI) with 3 dimensional surface reconstruction of the lesion site to precisely delineate the location of structural brain damage.