Novel signalling pathways leading to the activation of glomerular parietal epithelial cells

慢性肾脏疾病（CKD）是澳大利亚的一个主要健康问题。慢性肾病患者的治疗选择非常有限。大多数导致慢性肾病的疾病都与肾滤过器的瘢痕形成有关。壁上皮细胞位于这些过滤器中，在瘢痕形成中起关键作用。然而，导致这些肾过滤器瘢痕形成的分子机制尚不清楚。该建议旨在确定可能作为未来治疗靶点的分子途径。

Chronic kidney disease (CKD) is a major health problem in Australia. CKD patients have very limited therapeutic options. The majority of diseases that lead to CKD are associated scarring of the renal filters. Parietal epithelial cells reside in these filters and play key roles in scarring development. However, the molecular mechanisms that lead to scarring in these renal filters remain unclear. This proposal aims to identify molecular pathways that may serve as future therapeutic targets.