Control of immediate hypersensitivity responses in parasitic and other diseases

高嗜酸性粒细胞增多症已经得到了广泛的研究，我们已经确定了区分这种综合征的几个重要变体的新标记物。 利用流行病学工具，结合过敏性疾病的生理测量和免疫学评估，研究了蠕虫感染和过敏性疾病之间的相互作用。我们已经证明，慢性蠕虫感染可以预防过敏性疾病。到目前为止的研究表明，在慢性丝虫感染中，CD4+细胞(单核细胞和嗜碱性粒细胞都不是)是IL-10的压倒性主要来源。 我们已经开发了定量方法来检查每种抗体同种类型的生殖系转录，并开始使用这些方法来检查当抗原诱导特定开关重组事件时发生的分子事件。此外，还检测了过敏和寄生虫感染患者的基线IgE和IgG4生殖系转录谱，以及相关的IgE和IgG4水平升高。

Hypereosinophilic conditions have been studied extensively, and we have identified new markers that distinguish among several important variants of this syndrome. The interaction between helminth infeciton and allergic disease has been studied using epidemiological tools coupled with physiological measurements of allergic disease and immunological assessments. We have demonstrated that chronic helminth infection protects against allergic diseases. Studies done to date have demonstrated the CD4+ cells (and neither the monocytes nor the basophils) are the overwhelmingly major source of IL-10 in chronic filarial infection We have developed quantitative methods for examination of germline transcription for each of the antibody isotypes and have begun to use these methods to examine the molecular events that occur when antigens induce specific switch recombination events. Also baseline IgE and IgG4 germline transcription profiles have been measured in patients with allergic and parasitic infections and associated elevations of IgE and IgG4.