NIH Chemical Genomics Center

在本报告年度，NCGC与全球100多名研究人员合作，对分子靶点和细胞表型进行了50多次高通量筛选，这对几乎所有生物学和疾病领域都很重要，包括癌症、心脏病、传染病和神经系统疾病。在2008财年，发现了30多种不同生物的新化学探针，NCGC科学家发表了20多篇论文。其中包括治疗寄生虫病血吸虫病的新化合物，新的磷酸二酯酶-4抑制剂，首次报道的甲状腺刺激激素激动剂，以及修饰癌症基因表达的化合物。总的来说，生产指标包括筛选的50 - 5000万口复合井，产生的2亿个数据点，以及存入PubChem的3亿个数据点。

During the reporting year, the NCGC worked with over 100 researchers worldwide, and during the year performed over 50 high-throughput screens on molecular targets and cellular phenotypes important for virtually every area of biology and disease, including cancer, heart disease, infectious diseases, and neurological disorders. Over 30 new chemical probes of these diverse biologies were discovered, and NCGC scientists published over 20 publications during FY08. Among these were new compounds to treat the parasitic disease Schistosomiasis, new phosphodiesterase-4 inhibitors, the first reported thyroid stimulating hormone agonists, and compounds to modify gene expression in cancer. In all, production metrics included >50,000,000 compound wells screened, >200 million data points generated, and >300,000,000 data fields deposited into PubChem. The NCGC expanded its already-extensive outreach program during the year, in order to both educate the academic community about chemical genomics methods and capabilities, and assist researchers in their assay development efforts. NCGC staff delivered over 50 invited lectures worldwide during the year, from New York and San Francisco to Japan, Germany, and the U.K. During the year, the NCGC also successfully competed with chemical probe development centers all across the U.S. for the next phase of Molecular Libraries Roadmap funding, garnering the highest score of all applicants.