2010 Glycolipid & Sphingolipid Biology Gordon Research Conference

描述(由申请人提供)：将于2010年2月7日至12日在加利福尼亚州文图拉的文图拉海滩万豪酒店举行的戈登糖脂和鞘脂生物学研究会议申请部分资助(2012年大致相同)。会议的目的是鼓励在糖脂和鞘脂研究前沿工作的科学家社区内的思想和信息交流，并提供一个环境，让其他科学学科的研究人员可以了解这一快速发展的领域并为其做出贡献。鞘磷脂参与许多生物学过程，包括细胞生长、分化和凋亡，但这些功能的分子基础直到最近十年才变得清晰(即作为膜结构、细胞-细胞相互作用、受体功能的调节器，以及通过神经酰胺、鞘氨醇1-磷酸和其他有效的生物活性脂类的信号)。随着对鞘脂在疾病病因学和治疗中的作用--最明显的是癌症--的了解的发展，鞘脂类似物，如safingol，以及改变鞘脂代谢的抗癌化疗药物(如芬维甲素)已进入临床试验，表明该领域基础研究和翻译研究的密切合作。戈登会议的重要方面是，它汇集了在不同学科工作的科学家，如基础生物化学、遗传学、发育生物学、癌症化学预防和化学治疗，并鼓励高级研究人员和初级研究人员的参与。与本系列之前的戈登会议一样，与会者将有相当大比例来自美国以外的国家，女性和少数族裔也将参加。与会者将被鼓励参加正式的讲座/讨论会议，以及不那么正式的海报演示。平台会议将涵盖基础鞘脂生物学和生物化学方面的前沿研究，并将包括三个专门讨论鞘脂生物学的翻译方面的会议，特别是鞘脂在癌症、传染病中的作用及其作为毒素受体的作用。该方案将以面向未来的鞘脂组学会议结束，重点是鞘脂代谢和信号传递的整合，以期提供特定鞘脂在调节细胞生物学和病理生物学的特定方面的功能的综合模型。

DESCRIPTION (provided by applicant): Partial support is requested for the Gordon Research Conference on Glycolipid and Sphingolipid Biology, to be held at the Ventura Beach Marriott, Ventura, CA from February 7 - 12, 2010 (and approximately this same date in 2012). The purpose of the conference is to encourage the transfer of ideas and information within the community of scientists who work at the cutting edge of glycolipid and sphingolipid research as well as to provide an environment where investigators from other scientific disciplines can learn about, and contribute to, this rapidly evolving field. Sphingolipids participate in many biological processes, including cell growth, differentiation and apoptosis, but only in the past decade have the molecular bases for these functions become clear (i.e., as modulators of membrane structure, cell-cell interactions, receptor functions, and signaling via ceramide, sphingosine 1-phosphate and others potent bioactive lipids). As an understanding of the roles of sphingolipids in disease etiology and treatment--most notably for cancer--has evolved, sphingolipid analogs such as safingol as well as anticancer chemotherapeutics that modify sphingolipid metabolism (such as fenretinide) have entered clinical trials, illustrating the strong partnership of basic and translational research in this field. Important aspects of this Gordon Conference are that it brings together scientists that work in different disciplines, such as basic biochemistry, genetics, developmental biology, cancer chemoprevention and chemotherapy and that it encourages participation of both senior investigators and junior investigators. As with previous Gordon Conferences in this series, there will be a significant percentage of participants from countries outside the U.S. as well as participation by women and minorities. Conferees will be encouraged to participate both in the formal lecture/discussion sessions, and less formally in poster presentations. The platform sessions will cover leading edge research in basic sphingolipid biology and biochemistry, and will include three sessions devoted to translational aspects of sphingolipid biology, specifically, sphingolipids in cancer, in infectious diseases and their roles as toxin receptors. The program will close with a future-oriented session on sphingolipidomics, focusing on the integration of sphingolipid metabolism and signaling, with a view to providing a comprehensive model of the functions of specific sphingolipids in regulating defined aspects of cell biology and and pathobiology.