The Physiological Basis for Obesity Therapeutics

描述（由申请人提供）：本申请寻求FASEB夏季研究会议的部分资金：“肥胖治疗的生理基础。“这次会议的目标是：1.从综合的角度提出和讨论体重调节的关键方面，以及稳态和非稳态调节在特定人群中的差异; 2.介绍和讨论目前的治疗方法和正在开发的治疗方法如何影响这些调节系统，以及它们如何组合使用以提高其一般有效性和/或针对特定人群，在这些人群中它们可能更有效; 3.培养研究体重调节机制和肥胖个体治疗的初级科学家和临床医生。会议将于2009年8月16日至21日在科罗拉多的斯诺马斯村举行。通过这次会议，我们将试图建立一个基础科学研究人员和临床战略家之间互动的论坛，共同开发更好，更有效的治疗肥胖的疗法。调节能量稳态的生物系统本质上是多余的，在特定的个体群体中，体重调节存在细微差别。 我们还没有充分利用联合治疗的冗余或靶向治疗的这些细微差别。来自学术、营养和制药部门的科学家将在这次会议上会面，开始弥合基础科学和临床之间的差距。 超过60%的成年人超重或肥胖，目前的治疗方法不是很有效。本次会议将为科学家提供一个论坛，讨论肥胖治疗的更全面的观点，包括针对特定人群的组合策略。

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Research Conference on: "The Physiological Basis for Obesity Therapeutics." The objectives of this conference are: 1. To present and discuss the key aspects of body weight regulation from an integrative perspective, and how aspects of homeostatic and non-homeostatic regulation might differ in specific populations; 2. To present and discuss how current therapies and those in development affect these regulatory systems, and how they might be used in combination to improve their general effectiveness and/or targeted to specific populations in which they may be more effective; 3. To foster the development of junior scientists and clinicians who study the mechanisms of body weight regulation and the treatment of obese individuals. The conference will be held in Snowmass Village, Colorado, from August 16th to 21st, 2009. With this conference we will attempt to establish a forum for interaction between basic science researchers and clinical strategists to work together to develop better, more effective therapies to treat obesity. The biological systems regulating energy homeostasis are inherently redundant, and there are nuances in body weight regulation in specific groups of individuals. We have yet to fully capitalize on the redundancy with combination therapies or the presence of these nuances with targeted therapies. Scientists from academic, nutritional, and pharmaceutical sectors will meet at this conference and begin to bridge this gap between the basic sciences and the clinic. NARRATIVE: Over 60% of adults are overweight or obese, and current therapeutic approaches are not very effective. This conference will provide a forum for scientists to discuss a more comprehensive perspective of obesity therapeutics that involves targeting combinational strategies to specific populations.