Intersection of Exercise and Estrogen in Weight Regain After Weight Loss
Intersection of Exercise and Estrogen in Weight Regain After Weight Loss
批准号:
10712610
负责人:
Paul S. Maclean
金额:
$29.55万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
未结题
起止时间:
2012-09-20 至 2028-08-31
关键词:
AcylationAdipose tissueAppetite RegulationAttenuatedBackBioenergeticsBiologicalBody WeightBody Weight ChangesBody Weight decreasedCollaborationsDarknessDepositionDesire for foodDietDietary FatsDiseaseEatingEating BehaviorEnergy IntakeEnergy MetabolismEstradiolEstrogensExerciseExhibitsFatty acid glycerol estersFemaleFoundationsHormonesInjectionsIntakeKynurenineLightLinkLipidsLiverLongevityMaintenanceMediatingMenopauseMetabolismMolecular ProfilingMuscleObesityObservational StudyOvarianOvariectomyPancreasPathway interactionsPeptide YYPhysiologicalPre-Clinical ModelPunch BiopsyRattusRegulationRelapseRoleSex DifferencesTestingTherapeuticTissuesTracerTryptophanWeightWeight GainWeight maintenance regimenWomanWomen&aposs Healthcardiometabolismcostcytokineenergy balanceexercise trainingexperiencefeedingghrelinglucagon-like peptide 1gonad functioninsightlipid biosynthesismalemenneuralnovelobesity treatmentoverweight adultsoxidationpeptide hormonepre-clinicalpreventresponsesedentarysexsexual dimorphismtranscriptome sequencing
中文摘要
项目2 -项目总结
英文摘要
Project 2 – Project Summary
Over 60% of adults are overweight or obese. Obesity is particularly problematic in women who experience
unique physiological changes over their lifespan (e.g., menopause). While many weight-loss strategies exist,
weight regain after weight loss remains the largest barrier to successfully treating obesity. Regular exercise is
one of the most potent strategies for preventing weight regain after weight loss. We previously developed a
preclinical model showing that regular exercise reduces caloric intake during weight regain after weight loss.
Importantly, the exercise-induced reduction in caloric intake is observed in males and ovariectomized females
but not in intact/cycling female rats. In males, we have shown that regular exercise suppresses the drive to
overeat and potentiates energy expenditure above and beyond the cost of the exercise bout. The overall
objective of this proposal is to determine how exercise counters the biological drive to regain weight
and elucidate the sexual dimorphic response. To achieve this objective, we propose to investigate known
mechanisms of appetite and energy expenditure regulation that are thought to mediate the sex differences and
explore a novel role for the tryptophan-kynurenine (TRP-KYN) pathway in regulating energy balance in this
context.
In Aim 1, we will examine sex differences, the effect of ovariectomy, and the impact of exercise on
post-prandial gut hormone responses and eating behaviors and during weight regain. We hypothesize
that exercise is modulating gut hormone peptides to exert beneficial feeding effects during weight regain after
weight loss and that the presence of estrogen interferes with this modulation in intact females to sustain weight
regain.
In Aim 2, we will determine the impact of ovariectomy and estrogen add-back on exercise-induced
energy expenditure during weight regain after weight loss. We hypothesize that the exercise-induced
increase in energy expenditure is linked to its ability to enhance the capacity to oxidize fat, which is inherently
higher in females due to estrogen. We suspect the presence of estrogen in intact females and ovariectomized
females with estrogen add-back will diminish the impact of exercise on dietary fat oxidation and energy
expenditure.
In addition to testing these hypotheses, our studies will provide valuable information about TRP-KYN pathway
metabolites and their role in mediating the effects of sex differences, the loss of ovarian function, and the
beneficial effects of exercise training. Observations from these studies will provide insight into the
mechanisms of the sexual dimorphic response to exercise during weight regain and identify novel targets and
strategies to facilitate weight loss maintenance more effectively.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Postnatal Actions of Maternal Obesity on Neonatal Metabolic Health
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批准号:8841796
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项目类别:
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资助金额:$31.46万
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财政年份:2013
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负责人:Paul S. Maclean
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依托单位:
Postnatal Actions of Maternal Obesity on Neonatal Metabolic Health
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批准号:8584601
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资助金额:$32.06万
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财政年份:2013
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A Narrowed Window for Targeting Metabolic Flexibility in Breast Cancer Prevention
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批准号:8446908
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资助金额:$30.97万
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依托单位:
A Narrowed Window for Targeting Metabolic Flexibility in Breast Cancer Prevention
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批准号:8606440
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资助金额:$30.84万
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财政年份:2013
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负责人:Paul S. Maclean
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依托单位:
A Narrowed Window for Targeting Metabolic Flexibility in Breast Cancer Prevention
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批准号:8997453
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项目类别:
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资助金额:$32.27万
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财政年份:2013
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负责人:Paul S. Maclean
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依托单位:
Postnatal Actions of Maternal Obesity on Neonatal Metabolic Health
-
批准号:8703153
-
项目类别:
-
资助金额:$31.26万
-
财政年份:2013
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负责人:Paul S. Maclean
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依托单位:
Mediators of metabolic decline with the loss of gonadal function
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批准号:10456786
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项目类别:
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资助金额:$25.73万
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财政年份:2012
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负责人:Paul S. Maclean
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依托单位:
Mediators of metabolic decline with the loss of gonadal function
-
批准号:10225534
-
项目类别:
-
资助金额:$24.77万
-
财政年份:2012
-
负责人:Paul S. Maclean
-
依托单位:
The Physiological Basis for Obesity Therapeutics
-
批准号:7747639
-
项目类别:
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资助金额:$1.8万
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财政年份:2009
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负责人:Paul S. Maclean
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依托单位:
Functional aspects of SREBP1c in intact skeletal muscle
-
批准号:7235738
-
项目类别:
-
资助金额:$0.11万
-
财政年份:2005
-
负责人:Paul S. Maclean
-
依托单位:
Functional aspects of SREBP1c in intact skeletal muscle
-
批准号:7010383
-
项目类别:
-
资助金额:$13.23万
-
财政年份:2005
-
负责人:Paul S. Maclean
-
依托单位:
Functional aspects of SREBP1c in intact skeletal muscle
-
批准号:7157586
-
项目类别:
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资助金额:$13.33万
-
财政年份:2005
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负责人:Paul S. Maclean
-
依托单位:
Functional aspects of SREBP1c in intact skeletal muscle
-
批准号:6870847
-
项目类别:
-
资助金额:$13.02万
-
财政年份:2005
-
负责人:Paul S. Maclean
-
依托单位:
Colorado Nutrition Obesity Research Center
-
批准号:10046138
-
项目类别:
-
资助金额:$116.63万
-
财政年份:1997
-
负责人:Paul S. Maclean
-
依托单位:
Administrative Core
-
批准号:10457883
-
项目类别:
-
资助金额:$23.2万
-
财政年份:1997
-
负责人:Paul S. Maclean
-
依托单位:
Colorado Nutrition Obesity Research Center
-
批准号:10189558
-
项目类别:
-
资助金额:$116.63万
-
财政年份:1997
-
负责人:Paul S. Maclean
-
依托单位:
Administrative Core
-
批准号:10673797
-
项目类别:
-
资助金额:$23.2万
-
财政年份:1997
-
负责人:Paul S. Maclean
-
依托单位:
Colorado Nutrition Obesity Research Center
-
批准号:9750756
-
项目类别:
-
资助金额:$107.78万
-
财政年份:1997
-
负责人:Paul S. Maclean
-
依托单位:
Colorado Nutrition Obesity Research Center
-
批准号:10673762
-
项目类别:
-
资助金额:$116.63万
-
财政年份:1997
-
负责人:Paul S. Maclean
-
依托单位:
Colorado Nutrition Obesity Research Center
-
批准号:10199636
-
项目类别:
-
资助金额:$15.0万
-
财政年份:1997
-
负责人:Paul S. Maclean
-
依托单位:
海外基金