2009 Combinatorial Chemistry Gordon Research Conference

描述（由申请人提供）：本申请的目的是寻求美国国立卫生研究院的资金，以支持首届2009年戈登凯南研究生研究研讨会（GRS）题为组合化学：高通量化学和化学生物学。GRS将于2009年6月6日至7日在美国新罕布什尔州科尔比-索耶学院举行，同时将于6月7日至12日在新罕布什尔州科尔比-索耶学院举行2009年戈登组合化学会议（高通量化学和化学生物学）。整个GRC由Joseph M博士主持。Salvino在Cephalon，Inc.在费城，PA和副主席由迈克博士福利在布罗德研究所在波士顿，MA。 该GRS将为年轻的研究人员提供机会，展示他们在该领域最前沿的前沿研究方面的努力，引发激励性的互动和辩论。这将通过一个为期1.5天的会议来体现，包括10个学生/博士后研究人员会谈，两个海报会议和一个来自该领域杰出领导者的关键说明地址。总的来说，GRS的目标是50名年轻研究人员的出席，在轻松的气氛中提供一个优秀的科学论坛。 Jared Shaw博士（加州大学戴维斯分校）将成为GRS 2009年的首届主题演讲人。肖博士的研究体现了目前在这一领域所做努力的广度。Jared来自Broad Institute，在Broad Institute主任Stuart Schreiber教授的指导下工作。2006年秋天，他在加州大学戴维斯分校开始了自己的独立职业生涯。他的研究兴趣涵盖合成方法学、天然产物合成、多样性导向合成和化学生物学。他的演讲将是GRS唯一的教师演讲，其余的由学生/博士后研究人员演讲组成。两个海报会议将向所有参与者开放，他们将有机会在随后的大型GRC期间展示他们的海报，见下文。 这一就职GRS的发展将为该领域的高级科学家提供前所未有的机会，使学生和博士后研究人员互动，并将加强学生学习这一领域及其所包含的新技术之间的联系。组合化学研究中心有一个积极让少数民族参与者、妇女和残疾学生参与的强大传统，这一趋势将继续下去。卡尔风暴少数民族和国际多样性奖学金计划将被用来增加目前的资助工作。最终，GRS将提供一个很好的论坛，弥合充满热情和新想法的年轻研究人员与每天使用该技术的经验丰富的研究人员之间的差距。 公共卫生相关性：对用于高通量筛选（HTS）的高质量小分子文库的需求在分子文库开发和化学生物学的最前沿提出了巨大的挑战和机遇。最终，这些挑战的解决方案有助于发现分子先导物作为旨在改善人类健康的潜在治疗剂。1

DESCRIPTION (provided by applicant): The purpose of this application is to seek NIH funds to support the inaugural 2009 Gordon-Kenan graduate research seminar (GRS) entitled Combinatorial Chemistry: High Throughput Chemistry and Chemical Biology. The GRS will be held at Colby-Sawyer College, NH, USA from June 6-7, 2009, in conjunction with the 2009 Gordon Conference in Combinatorial Chemistry (High Throughput Chemistry and Chemical Biology) to be held from June 7-12th at Colby-Sawyer College, NH. The full GRC is chaired by Dr. Joseph M. Salvino at Cephalon, Inc. in Philadelphia, PA and vice-chaired by Dr. Mike Foley at the Broad Institute in Boston, MA. This GRS will provide young investigators the opportunity to present their efforts on cutting edge research at the forefront of the field, provoking stimulating interaction and debate. This will be manifested via a 1.5-day conference comprised of 10 student/postdoctoral researcher talks, two poster sessions and a Key Note address from an outstanding leader in this field. In all, the GRS is targeting an attendance of 50 young investigators providing an excellent scientific forum in a relaxed atmosphere. Dr. Jared Shaw (UC Davis) will be the inaugural GRS 2009 Keynote speaker. Dr. Shaw's research embodies the breadth of current efforts in this field. Jared emerged from the Broad Institute, working under the mentorship of the Professor Stuart Schreiber who is Director of the Broad Institute. He began his independent career at UC Davis in the fall of 2006. His research interests span synthetic methodology, natural product synthesis, diversity-oriented synthesis and chemical biology. His talk will be the only faculty talk at the GRS, the remainder comprised of student/postdoctoral researcher talks. The two poster sessions will be open to all participants who will have opportunity to also present their posters during the larger GRC to follow, vide infra. The development of this inaugural GRS will provide an unprecedented opportunity for senior scientists in the field to interact students and postdoctoral researchers and will strengthen the link between students learning about this field and the new technology it encompasses. The GRC on Combinatorial Chemistry has a Strong tradition of actively involving minority participants, women and students of disability, and this trend will be continued. The Carl Storm Minority and International Diversity Fellowship Program will be utilized to augment current funding efforts. Ultimately, the GRS will provide an excellent forum to bridge the gap between the young investigator full of enthusiasm and fresh ideas, and the seasoned researchers who utilize the technology on a daily basis. PUBLIC HEALTH RELEVANCE: The demand for high quality libraries of small molecules for use in high-throughput screening (HTS) has presented enormous challenges and opportunities at the forefront of molecular library development and chemical biology. Ultimately, solutions to these challenges serve to uncover molecular leads as potential therapeutic agents aimed at improving human health. 1