Eighth International Workshop on Molecular Aspects of Myeloid Stem Cell Developme

描述(由申请人提供)： 这项会议拨款是为第8届两年一度的研讨会“髓系干细胞发育和白血病的分子方面”提供的。第八次研讨会是自1995年以来举办的一系列研讨会，定于2009年5月10日至13日在马里兰州安纳波利斯的Loews Annapolis酒店举行。研讨会接待了约50名演讲者，共有约100人参加。白血病是一种造血干细胞疾病，分化受阻，扩增失控。研讨会的重点是位于白血病易位断裂点的基因，如AML1、TEL、RARA和MLL，以及由于表观遗传改变或突变导致的功能异常而异常表达的基因。这些因子的突变或异常水平与白血病的发生有因果关系。小鼠基因打靶研究和患者样本的序列分析表明，这些相同的基因对正常造血至关重要。这些因子在造血发育中的作用是组合的，重叠网络中相互作用的复杂性使得单个研究人员很难获得广泛的科学和临床视角来了解它们在正常造血和白血病发生中的作用。其目标是将在干细胞生物学、正常骨髓生成和白血病方面具有互补专业知识的研究人员聚集在一起。来自美国、英国、欧洲和日本的基础和临床科学家齐聚一堂，讨论他们在干细胞和造血调控因子方面的最新发现，例如转录因子，包括那些致力于研究骨髓增生异常综合征和白血病机制和治疗的科学家，以及通过基因突变或表观遗传修饰而失调的信号转导和细胞周期成分。其目的是通过非正式介绍和讨论交流信息。年轻的研究人员(研究生、博士后研究员)约占参与者的50%，他们有机会以海报或口头演讲的形式介绍他们的工作。参与者更好地了解了调节谱系指定和恶性造血的关键因素，以及它们在白血病方面的临床相关性。该研讨会以一种独特的方式将基础科学家、临床医生兼研究人员和初级研究人员聚集在一起，真正促进了正常和白血病干细胞和髓系发育方面的科学家之间的沟通和开放交流，未发表的结果，交叉受精和合作研究，以及转化性白血病研究和白血病治疗。(摘要结束)

DESCRIPTION (provided by applicant): This conference grant is for the 8th biennial workshop on "Molecular Aspects of Myeloid Stem Cell Development and Leukemia." This 8th workshop, in a series held since 1995, is scheduled for May 10-13, 2009 at the Loews Annapolis hotel in Annapolis, MD. The workshop hosts ~50 speakers, with a total of ~100 participants. Leukemia is a disease of hematopoietic stem cells that undergo a block in differentiation and a deregulated expansion. The workshop focuses on genes located at translocation breakpoints in leukemia such as AML1, TEL, RARa, and MLL, and on genes aberrantly expressed due to epigenetic alterations or function abnormally due to mutations. Mutations or abnormal levels of these factors are causally related to leukemogenesis. Murine gene-targeting studies and sequence analyses of patient samples show the critical importance of these same genes for normal hematopoiesis. The functions of these factors are combinatorial in hematopoietic development, and the complexity of interactions within overlapping networks makes it difficult for single investigators to gain wide scientific and clinical perspective to understand their roles in normal hematopoiesis and leukemogenesis. The goal is to bring together investigators with expertise in complementary aspects of stem cell biology, normal myelopoiesis and leukemia. Basic and clinician-scientists from the USA, England, Europe and Japan come together to discuss their latest findings on stem cells and hematopoietic regulators, e.g. transcription factors, including those who work on myelodysplastic syndrome and leukemia mechanisms and therapeutics, signal transducers and cell cycle components dysregulated through genetic mutations or epigenetic modifications. The aim is exchange of information through informal presentations and discussions. Young investigators (graduate students, postdoctoral fellows) comprise ~50% of participants and have the opportunity to present their work as posters or oral talks. Participants achieve greater understanding of the critical factors that regulate lineage specification and malignant hematopoiesis, and their relevance in the clinic in terms of leukemia. The workshop uniquely brings together basic scientist, clinician-investigators, and junior investigators in a manner that truly promotes communication and open exchange of ideas, unpublished results, cross-fertilization and collaborative research between scientists working on normal and leukemic stem cells and myeloid development, along with translational leukemia research and leukemia therapeutics. (End of Abstract)