4th International Eosinophil Symposium

请求为定于2005年5月25日至29日在瑞士伯尔尼大学医院举行的第四届国际嗜酸性粒细胞双年度研讨会和2007年举行的第五届双年度研讨会提供财政支助。这些两年一度的会议是在国际嗜酸性粒细胞协会(IES)的赞助下举行的。2005年会议将接待41位受邀的全体发言者和另外120位与会者，他们被邀请提交摘要，供青年科学家作“前沿”口头陈述和海报会议选择。会议从5月25日星期三的招待会开始，到5月29日星期日结束。当地组委会与国际咨询委员会和IES执行委员会协商，准备了一项基础、翻译和临床研究的尖端计划。研讨会为初级研究人员提供了口头和海报陈述的绝佳机会，并提供了全体会议，介绍这一重要的、多样化的和跨学科领域的最新进展。研讨会邀请了嗜酸性粒细胞研究和相关领域的领导人从哮喘、过敏、肺部、胃肠和寄生虫病的角度进行演讲，并包括一个新的Paul Erlich讲座，以及关于嗜酸性粒细胞研究未来方向的主旨演讲。重点放在嗜酸性粒细胞的细胞、分子和免疫生物学的基本方面，结合嗜酸性粒细胞在正常生理和疾病发病机制中的作用的翻译和临床研究。今年增加了关于嗜酸性胃肠道疾病、组织重塑和纤维化中的嗜酸性粒细胞、高嗜酸性粒细胞综合征的新致病方面以及抗嗜酸性粒细胞治疗策略的会议，包括讨论嗜酸性粒细胞生物学知识在药物中的应用。 嗜酸性粒细胞相关疾病的发现。研讨会是一个高度互动的研讨会式的论坛，供年轻科学家，特别是研究生、博士后研究员和初级教师的前沿摘要的口头和海报演示。下午故意不安排，以便有机会在会场内和周围进行科学讨论和社交/娱乐活动。研讨会的主题包括：(1)嗜酸性粒细胞发育、功能成熟(激活和抑制)和死亡的调节，(2)嗜酸性粒细胞疾病的动物模型，(3)嗜酸性粒细胞在胃肠道疾病中的作用，(4)嗜酸性粒细胞在先天免疫中的作用，(5)嗜酸性粒细胞对Th2免疫反应的调节，(6)嗜酸性粒细胞在组织重塑和纤维化中的作用，(7)高嗜酸性粒细胞综合征的新致病方面，以及(8)抗嗜酸性粒细胞治疗策略。 本次会议的中心目标是为变态反应、免疫学、血液学和癌症领域的初级和高级科学家之间的科学交流和合作提供一个高度互动的论坛，这些领域涉及正常宿主生理中的嗜酸性粒细胞的生物学和功能，以及疾病的病理生理学。

Financial support is requested for the 4th Biennial International Eosinophil Symposium, scheduled for May 25-29, 2005 at University Hospital, Bern, Switzerland, and the 5th Biennial Symposium in 2007. These biennial conferences are held under the auspices of the International Eosinophil Society (IES). The 2005 meeting will host 41 invited plenary speakers and an additional -120 participants who are solicited to submit abstracts for selection for "Cutting Edge" oral presentation and poster sessions by young scientists. The conference begins with a reception/orientation on Wed., May 25 and finishes on Sun., May 29. A cutting edge program of basic, translational, and clinical research has been prepared by the Local Organizing Committee in consultation with the International Advisory Committee, and the Executive Committee of the IES. The Symposium provides outstanding opportunities for oral and poster presentations by junior investigators, and plenary sessions on the most recent advances in this biomedically important, diverse and interdisciplinary field. The Symposium features invited talks by leaders in eosinophil research and allied fields from the perspectives of asthma, allergy, pulmonary, gastrointestinal and parasitic diseases, and includes a new Paul Erlich Lectureship, and Keynote Addresses on future directions in eosinophil research. The focus is on both basic aspects of eosinophil cellular, molecular and immunobiology, integrated with translational and clinical investigations of the roles of eosinophils in normal physiology and disease pathogenesis. Sessions on eosinophilic GI diseases, eosinophils in tissue remodeling and fibrosis, new pathogenic aspects of hypereosinophilic syndromes, and anti-eosinophil treatment strategies have been added this year, including discussions on applications of knowledge of eosinophil biology to drug discovery for eosinophil-associated diseases. The Symposium is a highly interactive, workshop-like, forum for both oral and poster presentations of cutting edge abstracts by younger scientists, particularly graduate students, postdoctoral fellows, and junior faculty. Afternoons are purposefully unscheduled to allow opportunities for scientific discussions, and social/recreational activities in and around the conference venue. The 4"' Symposium covers major themes on: (1) Regulation of Eosinophil Development, Functional Maturation (Activation and Inhibition), and Death, (2) Animal Models of Eosinophil Diseases, (3) Roles of Eosinophils in Gastrointestinal Diseases, (4) Eosinophils in Innate Immunity, (5) Eosinophil Regulation of Th2 Immune Responses, (6) Hosinophiis in Tissue Remodeling and Fibrosis, (7) New Pathogenic Aspects of Hypereosinophilic Syndromes, and (8) Anti-eosinophil Treatment Strategics. The central goal of this conference is to provide a highly interactive forum for scientific exchange and collaboration amongst junior and senior scientists in the fields of allergy, immunology, hematology, and cancer as relates to the biology and functions of the eosinophil in normal host physiology in health and pathophysiology in disease.