Making Muscle in the Embryo and Adult

描述(申请人提供)：克劳斯，罗伯特的“在胚胎和成人中制造肌肉”的申请请求部分支持，以召开一个国际会议，“在胚胎和成人中制造肌肉”。这是由肌肉生物学学会和FASEB分别主办的“肌肉发生前沿”和“骨骼肌卫星和干细胞”会议的联合会议。20多年来，这些会议每三年举行一次，而每两年举行一次，分别超过10年。由于这两次会议都计划在2009年春夏举行，而潜在的受众部分重叠，因此组织者联合起来，举行了一次包容性会议。会议将于2009年5月28日至6月2日在纽约市哥伦比亚大学校园举行，我们预计将吸引来自世界各地的300多名与会者。出于几个原因，本次会议的共同性质是重要和及时的。多年来，胚胎和成人的肌肉发生、发育和再生领域一直在融合，许多研究人员现在都在这两个领域工作，并进行了许多健康的交叉受精。虽然两次会议之间一直存在重叠，但2009年的会议将在大约10年内首次将两个完整的社区聚集在一起。这次会议的总体目标有两个：1)重点介绍肌肉发育、肌肉再生和肌肉干细胞生物学方面的调控机制的最新进展，并强调这些进展如何为肌病的潜在治疗提供信息；2)汇聚与肌肉疾病相关的发育、细胞和分子生物学、成人肌肉生物学、人类遗传学和翻译研究方面的专家，以便在基础和翻译水平上刺激新的研究和促进这些领域的合作。10次全体会议，63名发言者(20名从提交的摘要中挑选出来)，在高级、中期和初级级别，将讨论：躯体发生和肌肉发生；肌肉发生的转录调控；肌肉的模式；成肌细胞的分化；卫星细胞的发育起源；肌肉前体细胞的异质性；肌肉干细胞的生态位和命运；成人肌肉质量的调节；肌肉干细胞在癌症和衰老中的作用；以及肌肉疾病和治疗。将举行三个晚上的专门招贴会，包括这些领域。重要的是，这次会议的参与者代表了跨学科小组，他们将对该领域的最新发现进行全面的分析和整合。此外，会议将促进思想的交流和协作互动，这将有助于推动肌肉生物学的研究在未来几年取得进展。我们预计，自之前的“肌肉发生前沿”和“骨骼肌卫星和干细胞”会议以来，肌肉发育、肌肉干细胞和再生以及肌肉疾病方面取得的重大进展将使即将在纽约举行的这次联合会议成为这些肌肉生物学领域的研究人员的重要聚会。

DESCRIPTION (provided by applicant): Krauss, Robert's "Making Muscle in the Embryo and Adult" application requests partial support to convene an international meeting, "Making Muscle in the Embryo and Adult". This is a joint meeting of the "Frontiers in Myogenesis" and "Skeletal Muscle Satellite and Stem Cells" meetings that are sponsored by the Society for Muscle Biology and FASEB, respectively. These meetings have been held triennially for more than 20 years, and biennially for more than ten years, respectively. Because both meetings were scheduled to occur in Spring/Summer 2009, and the prospective audiences are partially overlapping, the organizers joined forces for a single inclusive meeting. The meeting will be held May 28 - June 2, 2009 on the campus of Columbia University, New York City, and we expect to attract more than 300 participants from around the world. The joint nature of this meeting is significant and timely for several reasons. The fields of embryonic and adult myogenesis, development and regeneration, have been converging for several years with many investigators now working in both areas and much healthy cross-fertilization. While there has always been overlap between the two meetings, this 2009 meeting will bring the two complete communities together for the first time in approximately ten years. The overall objective of this meeting is two- fold: 1) to highlight recent advances in regulatory mechanisms in muscle development, muscle regeneration, and muscle stem cell biology and to emphasize how these advances are informing potential therapies for myopathies; and 2) to bring together experts in developmental, cell and molecular biology, adult muscle biology, human genetics and translational research pertinent to muscle disease so as to stimulate new research and foster collaboration in these fields at both the basic and translational levels. Ten plenary sessions presenting 63 speakers (20 selected from the submitted abstracts), at the senior, mid-career and junior levels, will address: Somitogenesis and myogenesis; Transcriptional regulation of myogenesis; Patterning of muscle; Myoblast differentiation; Developmental origins of satellite cells; Heterogeneity of muscle precursor cells; Muscle stem cell niche and fate; Regulation of adult muscle mass; Muscle stem cells in cancer and aging; and Muscle diseases and therapies. Three evening dedicated poster sessions that comprise these areas will be held. Importantly, the participants of this conference represent interdisciplinary groups that will provide a comprehensive analysis and integration of recent discoveries in the field. Furthermore, the conference will promote cross-fertilization of ideas and collaborative interactions that will help drive study of muscle biology forward in the coming years. We expect that the major advances in muscle development, muscle stem cells and regeneration, and muscle disease that have taken place since the previous "Frontiers in Myogenesis" and "Skeletal Muscle Satellite and Stem Cells" conferences will make this upcoming, joint meeting in New York an essential gathering for investigators across these areas of muscle biology.