The 5th International Leukocyte Signal Transduction Workshop

描述（由申请人提供）：适当的免疫反应依赖于不同白细胞和其他细胞类型及其可溶性产物之间的复杂相互作用，以及许多受体之间的密集串扰，这些受体转导激活信号，导致细胞特异性基因程序的诱导、分化、增殖和效应功能的获得。失调的免疫反应会导致有害的结果，自身免疫性疾病的发展就是一个典型的例子。通过对小鼠的遗传操作，在很大程度上阐明了导致炎症和自身免疫发展的异常机制，从而对潜在的信号传导机制有了重要的了解。因此，信号通路在特定步骤上的遗传改变可以预防或诱导自身免疫和其他免疫疾病的发展。然而，小型的科学会议，允许密集的互动和富有成效的讨论，同时，把科学家聚集在一起研究白细胞信号传导途径的基本方面和这些途径的临床意义（包括相关的疾病模型）之间是很少的。请提供资金支持将于2009年6月13日至18日在希腊克里特岛举行的题为“第五届国际白细胞信号转导研讨会”的国际会议。这是自2000年以来举行的一系列类似会议中的第五次。以前的会议只关注白细胞受体信号转导的基本方面。即将召开的会议预计将有大约100名与会者，将汇集研究白细胞信号传导基本方面的科学家，以及研究动物疾病模型和这些信号传导途径临床意义的科学家。此外，几位特邀讲者将介绍和讨论相关的前沿技术。特邀教师由约25名国际知名科学家组成，他们是相关研究领域公认的专家。处于职业生涯早期形成阶段的科学家将优先参与和发言。讲习班的具体目标是：1。延续和延续先前的四次高效的白细胞信号转导研讨会。汇集国际知名科学家，他们是白细胞信号转导方面的专家，以及白细胞信号转导途径对炎症、自身免疫和传染病等疾病的影响，以介绍和讨论最新的相关研究。3. 给处于职业生涯早期阶段的科学家，即博士后研究员和研究生，特别是那些代表少数群体或来自发展中国家的科学家，一个机会来展示和讨论他们自己正在进行的工作，并从与顶尖科学家的密切、一对一的互动中受益，从而提供一种教育经验和动力，使他们致力于临床相关的科学研究事业。组织者期望这次研讨会将促进研究白细胞信号基本方面的科学家与研究动物模型（甚至人类）炎症和自身免疫性疾病的科学家之间的思想交流、密切互动和合作。请为“第五届国际白细胞信号转导研讨会”提供资金支持。本次研讨会是2000年发起的一系列卓有成效的会议中的第五次，将在希腊克里特岛举行，将有来自不同国家的约80-100名与会者参加，其中包括约22名国际知名演讲者的杰出教师，他们都是各自研究领域公认的领导者。会议的中心焦点将是免疫系统中不同细胞类型获得对入侵微生物进行有效免疫防御反应的能力的生化和分子机制，以及这些途径中的畸变如何导致自身免疫和炎症等免疫系统疾病。所要求的支助将主要用于支付登记和生活费用，对代表少数群体或来自发展中国家的受训人员给予最高优先。

DESCRIPTION (provided by applicant): A proper immune response depends on complex interactions between different leukocytes and other cell types and their soluble products, and on an intensive crosstalk among many receptors, which transduce activation signals leading to induction of cell-specific gene programs, differentiation, proliferation, and acquisition of effector functions. A dysregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example. Aberrant mechanisms that lead to development of inflammation and autoimmunity have been elucidated to a large degree by the genetic manipulation of mice, which led to significant insights into the underlying signaling mechanisms. Thus, genetic alteration of signaling pathways at defined steps can prevent or induce the development of autoimmunity and other immunological diseases. Nevertheless, small scientific meetings that allow intensive interactions and fruitful discussions and, at the same time, bring together scientists working on fundamental aspects of leukocyte signaling pathways and on the clinical implications of these pathways (including relevant disease models) are far and few between. Funds are requested to support an international conference entitled "The 5th International Leukocyte Signal Transduction Workshop" to be held in Crete, Greece, on 6/13-18/09. This is the 5th in a series of similar meetings, which were held since 2000. Previous meetings focused exclusively on basic aspects of signal transduction by leukocyte receptors. The program for the upcoming meeting, with ~100 anticipated participants, will bring together scientists working on fundamental aspects of leukocyte signaling, and those studying animal disease models and clinical implications of these signaling pathways. In addition, several invited talks will present and discuss relevant cutting edge technologies. The invited faculty consists of ~25 internationally known scientists who are recognized experts in relevant research areas. Scientists at the early, formative stage of their career will be given priority in participation and presentation. The Specific Aims of the Workshop are: 1. Extend and continue four previous, highly productive Leukocyte Signal Transduction Workshops. 2. Bring together internationally known scientists, who are experts in leukocyte signal transduction and the disease implications of leukocyte signaling pathways to, e.g., inflammation, autoimmunity, and infectious disease, in order to present and discuss the most up-to-date relevant research. 3. Give scientists at an early stage of their formative career, i.e., postdoctoral research fellows and graduate students, particularly those representing minority groups or coming from developing countries, an opportunity to present and discuss their own ongoing work and to benefit from close, one-on-one interactions with leading scientists, thereby providing an educational experience and a motivation to commit themselves to a clinically relevant scientific research career. The Organizers anticipate that this Workshop will promote sharing of ideas, close interactions and collaborations between scientists working on basic aspects of leukocyte signaling and those studying animal model (or even human) inflammatory and autoimmune diseases. Financial support is requested for a conference entitled "The 5th International Leukocyte Signal Transduction Workshop". This Workshop, the 5th in a series of highly productive meetings initiated in 2000, will be held in Crete, Greece, and will be attended by ~80-100 participants from different countries, including a distinguished faculty of ~22 internationally known speakers, who are all recognized leaders in their respective areas of research. The central focus of the meeting will be the biochemical and molecular mechanisms through which different cell types in the immune system acquire the ability to mount effective immune defense responses against invading microbes, and how aberrations in these pathways can lead to immune system diseases such as autoimmunity and inflammation. The requested support will mostly be used to defray the costs of meeting registration and subsistence costs, with the highest priority being given to trainees representing minority groups or from developing countries.