Sixth International Uppsala Conference on Electron Capture and Transfer Dissociat

描述（由申请人提供）：今年是电子捕获解离十周年-自那时起，ECD及其后代电子转移解离（ETD）已成为蛋白质序列分析领域的关键参与者。这些方法对于从完整蛋白质测序（自上而下）到大规模翻译后修饰分析的生物学应用至关重要。在过去的两年中，ETD使能的质谱仪已经广泛使用，至少有三种商业应用。我们估计，目前全球至少有150个ETD系统在运行--毫无疑问，其中大部分是用NIH的资金购买的。这些技术与更常见的碰撞激活方法非常不同，对大多数实验室来说都是新的。这些差异跨越基础，方法和信息方法。在这次会议上，我们寻求催化这些领域的信息的发展和传播，以推进蛋白质序列分析领域的发展，将领域领导人聚集在一起参加为期三天的会议。该计划将包括两个半天的讲座和海报会议。我们设想的时间表将允许25 - 30讲座来自世界各地的领域领导人。我们选择了世界著名的莫诺纳露台会议中心（由弗兰克劳埃德赖特设计）在麦迪逊，我们的州议会大厦的心脏，作为会场。我们预计出席人数约为100人，但计划免费网上直播整个会议。 公共卫生相关性： 相关性敏感蛋白质序列分析技术对于进一步了解人类生物学至关重要。电子捕获和转移解离是两种最近发展起来的技术，它们已经开始改变蛋白质序列分析的过程，包括翻译后修饰鉴定。这次会议将促进这一领域的进一步发展，并将使广大用户了解当前的最新技术。

DESCRIPTION (provided by applicant): This year marks the tenth anniversary of electron capture dissociation - since that time ECD and its offspring, electron transfer dissociation (ETD), have become key players in the field of protein sequence analysis. The methods are proving critical for biological applications ranging from intact protein sequencing (top-down) to large-scale post-translational modification analysis. In the past two years ETD-enabled mass spectrometers have become widely available with no less than three commercial implementations. We estimate at least 150 ETD systems are now operating worldwide - doubtless the majority of these were purchased with NIH funds. The techniques are very different from the more commonplace collision-activated approaches and are new to most laboratories. These differences span fundamentals, methods, and informatic approaches. At this meeting we seek to catalyze the development and spread of information in these areas for advancing the field of protein sequence analysis by bringing together field leaders for a three day conference. The program will consist of two and half days of lectures and poster sessions. We envision the schedule shall permit 25 - 30 lectures drawn from field leaders across the world. We have selected the world-renowned Monona Terrace Conference Center (designed by Frank Lloyd Wright) in the heart of Madison, our states capitol, as the venue. We anticipate an attendance of ~ 100, but plan to webcast the entire conference free of charge. PUBLIC HEALTH RELEVANCE: Relevance Technologies for sensitive protein sequence analysis are vital to further our understanding of human biology. Electron capture and transfer dissociation are two recently developed technologies that have already begun to transform the process of protein sequence analysis, including post-translational modification identification. This meeting with catalyze further development in this area and will make the current state-of-the-art known to the broad community of users.