Mouse Neuro-Recorder Headstage for Wide-band Microelectrode Signals

描述(由申请人提供)：AME建议开发和建造一种多通道宽带神经记录仪前台，可用于测量和记录小鼠的动作电位。神经记录仪将使用基于闪存的微型存储器将数据存储在本地，并在测试后将数据传输到PC。目前可用的神经记录头级只能记录小鼠的局部场电位，没有足够的带宽或内存来记录动作电位数据。拟议的头部阶段将推动动态动物神经监测的最先进水平，并使新的神经学研究成为可能。尽管传统上很难测量老鼠的体积，但老鼠是理想的研究对象，因为它们是可以遗传操作的。这使得小鼠能够适应其他物种所不能进行的科学实验，比如大鼠。这一拟议的设备将支持详细的动物神经学研究，这些研究支持包括阿尔茨海默氏症、亨廷顿病和癫痫在内的众多研究领域。公共卫生相关性：该设备将支持详细的动物神经学研究，支持包括阿尔茨海默氏症、亨廷顿病和癫痫在内的众多研究领域。

DESCRIPTION (provided by applicant): AME proposes to develop and build a multi-channel wideband neuro-recorder headstage that can be used for measuring and recording action potentials in mice. The neuro-recorder will use miniature flash-based memory to store data locally and transfer them to a PC post-testing. Currently available neuro-recording headstages only record local field potentials on mice and do not have enough bandwidth or memory to record action potential data. The proposed head stage will advance the state-of-the-art in ambulatory animal neurological monitoring and enable new neurological research. Despite being traditionally difficult to instrument due to their small size, mice are desirable subjects because they are genetically manipulable. This allows mice to accommodate scientific experiments that are unavailable in other species, such as rats. This proposed device will support detailed animal neurological studies, which support numerous research areas including Alzheimer's, Huntington's disease and epilepsy. PUBLIC HEALTH RELEVANCE: This device will enable detailed animal neurological studies, which support numerous research areas including Alzheimer's, Huntington's disease, and epilepsy.