Polyimide Neurotrophic Electrode Development: Fabrication and Testing

描述（由申请人提供）：提议的工作旨在进一步开发基于聚酰亚胺的神经营养电极，用于长期侵入性皮层记录。最初的神经营养电极是专门为长期记录而设计的，通过营养因子促进神经突生长成玻璃记录锥。电极设计可以进一步最小化和控制使用标准的微电子制造技术。将通过测量电特性（包括阻抗和功率谱密度）以及通过长期浸泡测试来评估制造的电极。公共卫生相关性：长期皮质记录电极的发展对脑机接口（bci）的进一步发展至关重要。脑机接口有可能减轻由肌萎缩性侧索硬化症（Lou Gehrig's disease）或下脑干中风引起的闭锁综合征患者的痛苦。

DESCRIPTION (provided by applicant): The proposed work seeks to further development of a polyimide-based Neurotrophic Electrode for long term invasive cortical recordings. The original Neurotrophic Electrode was specifically designed for long term recordings by encouraging neurite growth into a glass recording cone by trophic factors. The electrode design can be further minimized and controlled using standard microelectonic fabrication techniques. The fabricated electrodes will be evaluated by measuring the electrical characteristics, including impedance and power spectral density, and through long term soak tests. PUBLIC HEALTH RELEVANCE: The development of electrodes for long term cortical recordings is essential to further progress of Brain Computer Interfaces (BCIs). BCIs have the potential to alleviate the suffering of subjects with locked-in syndrome caused by ALS (Lou Gehrig's disease) or lower brain stem stroke.