Contaminate Removal For Laboratory Pharmaceutical Synthesis

描述(申请人提供)：大多数有机药物的化学合成都是在有机溶剂中进行的。有机溶剂中的氧气和/或水污染物会破坏许多有机反应物和有机金属试剂和催化剂。因此，氧气和水的去除是成功的有机合成的关键。不幸的是，氧气和水都是无处不在的，必须付出巨大的努力来去除氧气和水，并继续将它们排除在系统之外。在美国，几乎每个有机合成实验室都有一个从溶剂中去除氧气和水的系统。实验室在提纯溶剂方面有几个特别的顾虑。与从溶剂中去除氧气和水相关的三个主要问题是安全、成本和空间考虑。传统上，有机溶剂是通过蒸馏从活性金属中提纯出来的。这个第一阶段的项目将开发一种膜产品和工艺，以从反应溶剂和反应物中去除溶解氧和水。这种对氧气和水的关注在实验室合成中尤其如此。紧凑型膜系统公司提出了一种新的膜产品和工艺来解决这些问题。这种膜将是一种采用新型多孔载体和新型致密膜的复合结构。这一过程将既去除氧气和水，又保持它们的去除。膜系统原则上是通用的，而且成本非常低。我们将演示如何从代表性的溶剂中去除氧气和水。一旦污染物的去除完成，将与特拉华大学合作展示与去除水和氧有关的强化合成。紧凑型膜系统公司拥有众多的工业界和大学合作伙伴，他们对这项技术表现出了浓厚的兴趣。这些合作伙伴将在第一阶段计划以及随后的第二阶段活动和商业化方面提供帮助。 与公众健康相关：该项目将开发一种膜产品和工艺，以从反应溶剂和反应物中去除溶解氧和水。这一过程将既去除氧气和水，又保持它们的去除。膜系统原则上是通用的，而且成本非常低。这一发展将代表着CMS膜技术的应用，对与药物制造相关的生产成本具有相当大的意义。

DESCRIPTION (provided by applicant): Most organic pharmaceutical chemical syntheses are done in organic solvents. Oxygen and/or water contaminants in organic solvents will destroy many organic reactants and organometallic reagents and catalysts. As such, the removal of oxygen and water are critical to successful organic synthesis. Unfortunately both oxygen and water are ubiquitous and significant effort must be introduced to both remove oxygen and water and continue to keep them out of the system. Nearly every organic synthesis laboratory in the United States has a system for the removal of oxygen and water from solvents. Laboratories have several special concerns with respect to the purification of solvents. The three major concerns associated with oxygen and water removal from solvents are safety, cost and space considerations. Traditionally, organic solvents have been purified by distillation from reactive metals. This Phase I project will develop a membrane product and process to remove dissolved oxygen and water from reaction solvents and reactants. This concern for oxygen and water is especially true in laboratory synthesis. Compact Membrane Systems, Inc. proposes a novel membrane product and process to address these issues. This membrane will be a composite structure using a novel porous support and novel dense membrane. The process will both remove the oxygen and water and maintain their removal. The membrane system is in principle universal and very low cost. The removal of oxygen and water from representative solvents will be demonstrated. Once the removal of contaminants is completed, enhanced synthesis related to removal of water and oxygen will be demonstrated working with the University of Delaware. Compact Membrane Systems has numerous industrial and university partners which have shown a strong interest in this technology. These partners will be helpful in the Phase I program and subsequent Phase II activity and commercialization. PUBLIC HEALTH RELEVANCE: This project will develop a membrane product and process to remove dissolved oxygen and water from reaction solvents and reactants. The process will both remove the oxygen and water and maintain their removal. The membrane system is in principle universal and very low cost. This development will represent an application of CMS membrane technology that has considerable significance to production costs related to pharmaceutical manufacturing.