Obstructive Sleep Apnea and Androgen Dysregulation

阻塞性睡眠呼吸暂停（OSA）是一种严重的公共卫生问题，与嗜睡增加、心脏病和代谢功能障碍有关。肥胖和男性是OSA的重要易感因素。这项研究将确定短期睾酮治疗是否有助于改善节食和锻炼的男性的阻塞性睡眠呼吸暂停。它还将确定睾丸激素可能影响睡眠和肥胖期间呼吸的遗传机制。

Obstructive Sleep Apnea (OSA) is a serious public health problem associated with increased sleepiness, heart disease and metabolic dysfunction. Obesity and male gender are important predisposing factors for OSA. This study will determine if short-term testosterone therapy can help improve OSA in men who are also dieting and exercising. It will also determine the genetic mechanisms by which testosterone might influence breathing during sleep and obesity.