ORS Musculoskeletal Biology Workshop at Zermatt

描述 本申请请求支持ORS肌肉骨骼生物学研讨会第50届年会， 在爱达荷州的太阳谷举办了20多年。2022年，研讨会迁往犹他州 落基山脉，就在盐湖城外。2023年研讨会将在犹他州米德兰泽马特度假村举行， 2023年7月21日至25日。根据与会者的反馈，研讨会被转移到新地点 在过去的几年里，世卫组织表示希望在一个成本较低的地点举行会议 也更容易到达。在新的地点，我们实现了这两个方面的改进。这次会议 它本身将保持几十年来所享有的精神：它强调青少年的积极参与 教师和学生；促进跨学科交流；不同寻常的是，讨论的时间相等 或超过正式陈述所分配的时间。研讨会的目标是：(1)致力于 分子、组织和生物力学过程的多学科基础和临床综合 肌肉骨骼组织，帮助我们了解骨、肌肉和软骨疾病的发病机制 及其预防和治疗；(2)将基本科学概念应用于临床问题；开展对话 基础研究人员和临床研究人员之间的合作，导致跨学科合作；(3)确定有意义的 肌肉骨骼疾病的问题，并确定提供解决方案的实验方法和 (4)为学生培训提供论坛，并在小组环境中为初级科学家提供发言机会 和更资深的科学家一起。研讨会与矫形外科研究会之间的伙伴关系 (ORS)通过广播电子邮件和ORS网站上的链接提供最大程度的可见性。今年我们 继续我们新设立的对解决问题的关注，研讨会的主题是 肌肉骨骼细胞：识别、靶向、刺激和操纵以获得治疗收益。六节课 解决相关和重大的当前问题，包括罕见骨骼疾病的当前挑战， 骨关节炎生物学方面的最新突破，骨靶向分子的进展 提供治疗的工具，对破骨细胞起源和命运的新见解，骨骼干细胞的进展， 以及机械生物学和成像的交叉点。这个研讨会的一个显著特点是，它正在成为 一个真正的肌肉骨骼研讨会，考虑骨骼以外的肌肉骨骼状况的问题。 主要焦点仍然是骨骼。为初级调查人员提供与更高级的调查人员互动的机会 调查人员。将有两个专门针对年轻调查人员的职业发展会议 指挥。十位ASBMR/Frost青年研究员奖获得者将在领奖台上介绍他们的工作。十个或 更多Jee Young调查员奖亦会派发，以增加青年调查员的出席率和 参与。

Description This application requests support for the 50th annual meeting of the ORS Musculoskeletal Biology Workshop, which had been held at Sun Valley, Idaho, for the past 20+ years. In 2022 the Workshop moved to the Utah Rockies, just outside Salt Lake City. The 2023 workshop will be held in Midland, Utah at the Zermatt Resort, from July 21-25, 2023. The Workshop was moved to the new location in response to feedback from attendees over the past several years, who expressed a desire to have the meeting at a venue that was less expensive and easier to get to. We have achieved both of those improvements with the new location. The conference itself will maintain the same spirit it has enjoyed for several decades: it emphasizes active participation of junior faculty and students; promotes interdisciplinary communication; and is unusual in that discussion time equals or exceeds time allotted for formal presentation. The goals of the Workshop are to (1) work toward a multidisciplinary basic and clinical synthesis of molecular, tissue and biomechanical processes in musculoskeletal tissues that help us to understand the pathogenesis of bone, muscle, and cartilage disease as well as its prevention and treatment; (2) apply basic science concepts to clinical problems; develop a dialogue between basic and clinical investigators that leads to interdisciplinary collaboration; (3) identify significant problems in musculoskeletal disease, and identify experimental approaches that provide solutions to them and (4) provide a forum for student training and the opportunity in a small group setting for junior scientists to talk with more senior scientists. A partnership between the Workshop and the Orthopaedic Research Society (ORS) provides maximum visibility through broadcast emails and links on the ORS website. This year we continue our newly instituted focus on problem solving, with the theme for the Workshop being “Musculoskeletal cells: identity, targeting, stimulation, and manipulation for therapeutic gain.” Six sessions address relevant and significant current problems, including current challenges with rare skeletal disease, recent breakthroughs in our understanding of the biology of osteoarthritis, progress in bone-targeting molecular tools for delivery of therapeutics, new insights into osteoclast origin and fate, advances in skeletal stem cells, and the intersection of mechanobiology and imaging. A notable feature of this Workshop is that it is becoming a truly musculoskeletal workshop, considering problems of musculoskeletal conditions beyond bone, though the major focus remains bone. Opportunities are provided for junior investigators to interact with more senior investigators. Two Career Development sessions specifically geared toward young investigators will be conducted. Ten ASBMR/Frost Young Investigator Awardees will present their work from the podium. Ten or more Jee Young Investigator Awards will also be distributed to increase young investigator attendance and participation.