Pediatric Template of Brain Perfusion

描述（由申请人提供）：我们提出“儿童大脑结构和功能集成模板”——一种对发育中的大脑进行多变量定量图像评估。该模板将对所有人开放，并将用于列举工作记忆性能与皮层和连接成熟之间的相互作用。母项目的首要目标是验证、构建和分发一个基于核磁共振成像的统计图谱（或模板），该图谱描述了“正常”儿童大脑中的血流模式（或灌注）的发展轨迹及其对工作记忆任务的反应。在这里，我们通过额外的、最先进的扫描，为从这一大型队列收集的成像数据集增加了深度。我们还通过引入尖端的计算神经解剖学和多元统计处理来梳理出跨模态相互作用、网络节点关系及其对认知处理的影响，从而增加了相关分析的严谨性和广度。特别是，我们通过先进的扩散张量成像，尖端的皮质厚度和分析以及参数的多元稀疏回归，以及灌注和工作记忆性能来实现这一目标。

DESCRIPTION (provided by applicant): We propose "An Integrated Pediatric Template of Brain Structure and Function" - a multivariate quantitative image assessment of the developing brain. The template will be openly available to all and will be used to enumerate the interaction between working memory performance and cortical and connectivity maturation. The parent project's over-arching aim is validate, construct and distribute a MRI-based statistical atlas (or template) that describes the developmental trajectory of blood flow patterns (or perfusion) in the "normal" pediatric brain and its responses to working memory tasks. Here, we add depth to the imaging dataset collected from this large cohort through additional, state-of-the-art scanning. We also add rigor and breadth of appeal to the associated analysis by introducing cutting-edge computational neuroanatomy and multivariate statistical processing to tease out cross-modality interactions, network-node relationships and effects of these on cognitive processing. In particular, we achieve this through advanced diffusion tensor imaging, cutting-edge cortical thickness and analyses and multivariate sparse regression of the parameters, along with perfusion, and working memory performance. PUBLIC HEALTH RELEVANCE: This proposal responds to public health needs through large-scale data collection that enables studies of cross-sectional sex differences in developmental trajectories and behavior. Secondly, the proposal supports longitudinal neuroimaging studies in mental disorders by performing a normative 4 time point multi-modality study of normal longitudinal development in 30 children.