De-coding Cis-regulatory information on a Genome-Wide Level with Single Neuron Re

描述（由申请人提供）：神经系统的特征在于细胞多样性的惊人程度，但我们对创造这种多样性的机制的见解是有限的。与神经元多样性相关的分子是神经元类型特异性基因表达程序。表征单个细胞类型的共表达基因组通常被称为基因电池，其通过其与保守的共同顺式调控元件的连接来定义。在全基因组水平上，对单个神经元亚型的基因组性质及其相关的顺式调节元件的描述很少。我们建议在这里系统地解码顺式调控信息的全基因组水平，并确定一个单一的神经元特异性基因表达程序的身份。

DESCRIPTION (provided by applicant): Nervous systems are characterized by an astounding degree of cellular diversity, yet our insights into the mechanisms of creating this diversity are limited. The molecular correlate to neuronal diversity are neuron-type specific gene expression programs. Sets of co-expressed genes that characterize an individual cell type are commonly referred to as gene batteries which are defined by their linkage to conserved, common c/s-regulatory elements. The nature of gene batteries for individual neuronal subtypes as well as their linked cis-regulatory elements are poorly described on a genome-wide level. We propose here to systematically decode cis-regulatory information on a genome-wide level and to determine the identity of a single neuron-specific gene expression program.