Treatment of Uveitic Cystoid Macular Edema with Topical Interferon Gamma
Treatment of Uveitic Cystoid Macular Edema with Topical Interferon Gamma
批准号:
7976142
负责人:
DARBY THOMPSON
金额:
$5.56万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-11-01 至 2011-10-31
中文摘要
外用干扰素伽玛刀治疗葡萄膜囊样黄斑水肿
葡萄膜炎是一种严重的炎症状态,会影响眼睛,并可能导致视力丧失。与葡萄膜炎相关的一个常见的次要问题是黄斑水肿(肿胀)。黄斑是眼睛中对中心视力很重要的部分,黄斑的肿胀会导致进一步的视力丧失。这种情况通常是通过针对免疫系统的药物来治疗的,但这些药物有时不起作用,或者可能会产生副作用。
-干扰素GAMA-1b(Actimmune(注册商标))是一种生物工程蛋白质,可以改变炎症细胞在免疫系统中的工作方式。干扰素伽马-1b以肌肉注射的形式给予;然而,这项研究将该药物用作眼药水。这项研究是干扰素伽马-1b第一次作为眼药水使用。研究人员希望干扰素Gamma-1b可以通过减少背部肿胀来治疗黄斑水肿。
英文摘要
The Treatment of Uveitic Cystoid Macular Edema with Topical Interferon Gamma
Uveitis is a serious inflammatory condition that affects the eye and can cause vision loss. A common secondary problem associated with uveitis is macular edema (swelling). The macula is the part of the eye that is important for central vision, and swelling of the macula can lead to further vision loss. This condition is usually treated by medicines that target the immune system, but these medicines sometimes do not work or may cause side effects.
- Interferon gamma-1b (Actimmune(Registered Trademark)) is a bioengineered protein that can alter the way inflammatory cells work in the immune system. Interferon gamma-1b is given as an intramuscular injection; however, this study will use the drug as an eye drop. This study represents the first time that interferon gamma-1b is given as an eye drop. Researchers hope that interferon gamma-1b will treat macular edema by decreasing the swelling in the back
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会议论文
Epigenetics, Molecular Genetics, and Biomarkers of Inflammatory Ocular Diseases
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批准号:7975994
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项目类别:
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资助金额:$13.93万
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财政年份:2006
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负责人:DARBY THOMPSON
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负责人:DARBY THOMPSON
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Age-Related Macular Degeneration: A Genetic Epidemiology Study in the Amish
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批准号:7963499
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资助金额:$20.0万
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负责人:DARBY THOMPSON
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资助金额:$13.93万
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负责人:DARBY THOMPSON
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依托单位:
Vitreous Proteome and Inflammatory Mediators in Ocular Inflammatory Disease
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批准号:7975936
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项目类别:
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资助金额:$13.93万
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财政年份:2006
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负责人:DARBY THOMPSON
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Age-Related Eye Disease Study (AREDS) Follow-Up
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批准号:7975982
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资助金额:$8.11万
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资助金额:$14.2万
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财政年份:2006
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负责人:DARBY THOMPSON
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Clinical and Molecular Studies in Families with Myopia and Related Diseases
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资助金额:$13.93万
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负责人:DARBY THOMPSON
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Intravitreal Inj of Ranibizumab for Macular Telangiectasia w/o Neovascularization
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资助金额:$4.31万
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财政年份:2006
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负责人:DARBY THOMPSON
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Trial of Cysteamine in Treatment of Corneal Cystine Accumulation in Cystinosis
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项目类别:
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资助金额:$0.66万
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财政年份:2006
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负责人:DARBY THOMPSON
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依托单位:
Immunopathology and Molecular Pathology of Ocular Diseases in Humans
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批准号:8075857
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项目类别:
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资助金额:$0.66万
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财政年份:2006
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负责人:DARBY THOMPSON
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依托单位:
Epigenetics, Molecular Genetics, and Biomarkers of Inflammatory Ocular Diseases
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批准号:8075868
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项目类别:
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资助金额:$0.66万
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负责人:DARBY THOMPSON
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Screening Study for the Evaluation and Diagnosis of Research Participants
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资助金额:$5.0万
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负责人:DARBY THOMPSON
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Subconjunctival Sirolimus for Treatment of Autoimmune Active Anterior Uveitis
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资助金额:$13.93万
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财政年份:2006
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负责人:DARBY THOMPSON
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依托单位:
Vitreous Proteome and Inflammatory Mediators in Ocular Inflammatory Disease
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批准号:8075860
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项目类别:
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资助金额:$0.66万
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财政年份:2006
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负责人:DARBY THOMPSON
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批准号:8075870
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项目类别:
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资助金额:$0.66万
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财政年份:2006
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负责人:DARBY THOMPSON
-
依托单位:
海外基金