Lisdexamfetamine treatment for cocaine dependence

这项提案请求支持K99/R00独立之路奖的Roo阶段，使David Herin博士能够开始他的独立职业生涯，研究药物滥用的药理治疗。该奖项的第一阶段(K99)由John Grabowski博士和喜悦Schmitz博士在德克萨斯大学休斯顿健康科学中心(UTHSC)进行。在这一阶段，赫林博士完成了临床试验方法学、先进的统计方法、负责任的研究指导以及专业技能方面的培训。此外，Herin博士在UTHSC P50药物开发中心的多项研究中获得了实施临床试验的经验，并与院系教员建立了合作关系。这种临床培训使赫林·罗博士在明尼苏达大学精神病学系获得了一个终身教职。随着Herin博士开始他的独立职业生涯，Roo的支持将使他能够进行一项临床试验，调查lisdexamfetamin治疗可卡因依赖的能力。在Roo期间，Herin博士还将与他在明尼苏达大学的同事们在功能成像等领域展开合作， 冲动、遗传学和人体实验室研究，使未来向资助机构提交跨学科拨款申请成为可能。总而言之，K99和Roo奖项允许Herin博士开始他的独立职业生涯，并在药物滥用研究领域做出重大科学贡献。

This proposal requests support for the ROO phase of the K99/R00 Pathway to Independence Award enabling David Herin, Ph.D, to begin his independent career investigating pharmacological treatments for substance abuse. The first (K99) phase ofthis award has been conducted at the University of Texas Health Science Center at Houston (UTHSC) under Drs. John Grabowski and Joy Schmitz. In this phase, Dr. Herin completed training in clinicai trials metholodology, advanced statistical methods, the responsible conduct of research, as well as u-aining in professional skills. Additionally, Dr. Herin obtained experience in implementation of clinical trials in multiple studies at the UTHSC P50 medication development center, and developed collaborations with departmental faculty. This clinical training has enabled Dr. Herin lo secure a tenure-track faculty position in the Department of Psychiatry at the University of Minnesota. As Dr. Herin launches his independent career, ROO support will enable him to conduct a clinical trial investigating the ability of lisdexamfetamine to treat cocaine dependence. During this ROO period, Dr. Herin will also develop collaborations with his University of Minnesota colleagues in fields such as functional imaging, impulsivity, genetics, and human laboratory studies, enabling submission of future interdisciplinary grant applications to funding agencies. In all, the K99 and ROO awards permit Dr. Herin to begin his independent career and make significant scientific contributions to the field of substance abuse research.