Graduate Training in Biochemistry and Molecular Biology

描述(由申请人提供):BMCB、生物化学、分子和细胞生物学、培训项目目前已经43岁的博士生努力程度。2008年秋季入学的一年级新生有10名。这些研究兴趣包括生物化学：金属结合和核酸结合蛋白的x射线晶体学分析，热休克蛋白功能，核苷酸合成的酶学，脂肪酸/硫辛酸生物合成的调节，脂联素信号传导，分子生物学：基因组结构分析，DMA修复和染色体不稳定性，RNA加工，周转和运输，细胞生物学。癌细胞发生和转移的调节，细胞器的生物发生和放置，细胞骨架结构和功能，到发育：控制模式形成的信号通路，发育程序的进化，心脏发育。二年级及以上的学生将根据成绩选择，最多可获得两年的培训资助。所有BMCB学生将参加每周的期刊俱乐部和研讨会项目；每年每个学生至少要做一次报告。每年举行一次静修会，每位学生展示一张海报或演讲，这是BMCB长期以来的传统。一年级和二年级的学生要完成一系列课程，包括核酸、蛋白质和酶。生物化学专业的学生选修生物结构，MCB专业的学生选修细胞系统。为对生物信息学感兴趣的学生开设的新课程将包括计算机辅助基因组分析课程。预计我们的许多毕业生将成为教授，教师和/或实验室主任，所有学生将在亚利桑那大学接受至少一个学期的本科生物化学和分子与细胞生物学课程的助教培训。学生将参加年度强制性会议，审查即将到来的一年的项目要求，并将通过项目的里程碑独立监督进展情况。所有学生都将有一个教师指导委员会，该委员会每年至少召开一次会议。

DESCRIPTION (provided by applicant): The BMCB, Biochemistry, Molecular and Cellular Biology, Training Program presently has 43 Ph.D. students working toward the degree. Ten new students have been admitted for the 2008 Fall first-year class. These research interests range from biochemistry: x-ray crystallographic analysis of metal binding and nucleic acid binding proteins, heat shock protein function, enzymology of nucleotide synthesis, regulation of fatty acid/lipoic acid biosynthesis, and adiponectin signalling, to molecular biology: genome structure analysis, DMA repair and chromosome instability, RNA processing, turnover and transport, to cellular biology: regulation of cancer cell genesis and metastasis, organelle biogenesis and placement, cytoskeleton structure and function, to development: signaling pathways governing pattern formation, evolution of developmental programs, heart development. Students in the second year and beyond will be chosen based on merit for a maximum of two years of support by this training grant. All BMCB students will participate in weekly journal club and seminar programs; each year each student will give at least one presentation. A yearly retreat where each student either presents a poster or a talk is a long-standing BMCB tradition. First and second year students complete a set of courses that includes Nucleic Acids and Proteins and Enzymes. Students in the Biochemistry track take Biological Structure and those in the MCB track take Cellular Systems. A new track for students interested in Bioinformatics will include a course in computer-aided analysis of genomes. In anticipation that many of our graduates will become professors, teachers and/or laboratory heads, all students will be trained as teaching assistants in the undergraduate Biochemistry and Molecular and Cellular Biology classes at the University of Arizona for at least one semester. Students will attend yearly mandatory meetings to review program requirements for the upcoming year and will be monitored independently for progress through the milestones of the program. All students will have a faculty mentoring committee that will meet at least once a year.