CML Cell Bank

M.D.安德森癌症中心CML-P01的主要目标是改善患者的治疗 患有慢性粒细胞白血病。实现这一目标的一个基本组成部分是进行 涉及人体组织和血液样本的有重点的翻译研究，允许调查 靶组织和正常组织的生物学，对靶组织和正常组织的治疗效果的评估，以及 相关生物标志物的调控。慢性粒细胞白血病细胞库核心将收集、处理和维护人体组织 并将这些组织分发给CML-P01调查人员。 慢性粒细胞白血病细胞库核心有以下目标： 1.建立和维护一个完整的细胞、血清、DNA、RNA和来自血液和 取自正在M.D.接受治疗或评估的CML患者的骨髓标本。 安德森癌症中心。样本在诊断时、治疗期间收集和处理。 在缓解或复发时使用POI相关临床方案。核心将分布组织 将标本交给CML-P01调查人员进行分析并提供研究解释方面的专业知识 在CML-P01项目中进行组织切片，核心将提供全面的 CML-P01项目中使用的样本的血液病理学特征。 2.为CML-P01研究人员提供现货和定制的反相蛋白质阵列。 3.维护一个包含详细临床和病理数据的全面、前瞻性的交互数据库 适用于在M.D.安德森癌症中心接受护理或评估的白血病和MDS患者。

The primary objective ofthe M.D. Anderson Cancer Center CML-P01 is to improve the treatment of patients with chronic myelogenous leukemia. A fundamental component to meeting this objective is the conduct of focused translational research involving human tissue and blood specimens, allowing investigation of the biology of target and normal tissues, evaluation of treatment effects on both target and normal tissue, and modulation of relevant biomarkers. The CML Cell Bank Core will collect, process and maintain human tissue specimens from patients and will disperse these tissues to CML-P01 investigators. The CML Cell Bank Core has the following objectives: 1. Develop and maintain a repository of intact cells, serum, DNA, RNA and protein derived from blood and bone marrow specimens obtained from patients with CML that are receiving care or evaluation at M.D. Anderson Cancer Center. Samples are collected and processed at the time of diagnosis, during therapy with POI associated clinical protocols, while in remission or at relapse. The core will distribute tissue specimens to CML-P01 investigators for analysis and provide expertise in the interpretation of studies performed on tissue sections within CML-P01 projects The Core will provide comprehensive hematopathologic characterization ofthe samples used in CML-P01 projects. 2. Provide stock and customized Reverse Phase Protein Arrays to CML-P01 researchers. 3. Maintain a comprehensive, prospective interactive database with detailed clinical and pathologic data for patients with leukemia and MDS receiving care or evaluation at M.D. Anderson Cancer Center.